[1]邱 滔,罗 鸿,吕新宇.4-氨基-2-(环丙胺基)-5-氰基-6-甲硫基嘧啶的氧化[J].常州大学学报(自然科学版),2012,(02):28-30.
　QIU Tao,LUO Hong,LV Xin-yu.Study of the Oxidation of 4-Amino-2-(Cyclopropylamino)-6- (Methylthio)Pyrimidine-5-Carbonitrile[J].Journal of Changzhou University(Natural Science Edition),2012,(02):28-30.
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4-氨基-2-(环丙胺基)-5-氰基-6-甲硫基嘧啶的氧化()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2012年02期
页码:
28-30
栏目:
出版日期:
2012-03-30

文章信息/Info

Title:
Study of the Oxidation of 4-Amino-2-(Cyclopropylamino)-6- (Methylthio)Pyrimidine-5-Carbonitrile
作者:
邱 滔; 罗 鸿; 吕新宇
常州大学 设计研究院,江苏 常州 213164
Author(s):
QIU Tao; LUO Hong; LV Xin-yu
Institute of Design and Research,Changzhou University,Changzhou 213164,China
关键词:
氧化;  过氧化尿素;  过硫酸氢钾
Keywords:
oxidation;  urea peroxide;  potassium peroxymonosulfate
分类号:
R 914.5
文献标志码:
A
摘要:
用过氧化尿素,双氧水,过硫酸氢钾等氧化剂,对4-氨基-2-(环丙胺基)-5-氰基-6-甲硫基嘧啶进行氧化研究,得到4-氨基-2-(环丙胺基)-5-氰基-6-甲磺酰基嘧啶,并对其工艺路线做了优化。确定n(4-氨基-2-(环丙胺基)-5-氰基-6-甲硫基嘧啶):n(钨酸钠):n(乙酸):n(过氧化尿素):n(二氯甲烷)=1:0.002:1.48:3:20。
Abstract:
Urea peroxide,hydrogen peroxide and potassium persulfate were used as oxidants to study the oxidation of 4-amino-2-(cyclopropylamino)-6-(methylthio)pyrimidine-5-carbonitrile.Successful oxidation of 4-amino-2-(cyclopropylamino)-5-cyano-6-methylsulfonylpyrimidine and the process route were optimized.The mole ratio n(4-amino-2-(cyclopropylamino)-6-(methylthio)pyrimidine-5-carbonitrile)was determined:n(sodium tungstate):n(acetic acid):n(urea peroxide):n(dichloromethane)=1:0.002:1.48:3:20.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:邱滔(1967-),男,江苏常州人,研究员。
更新日期/Last Update: 2012-03-30