[1]周舒文,徐德锋,杨幸群,等.脂质体的粒径大小对二甲基姜黄素抗癌能力的影响研究[J].常州大学学报(自然科学版),2016,(06):14-17.[doi:10.3969/j.issn.2095-0411.2016.06.003]
　ZHOU Shuwen,XU Defeng,YANG Xingqun,et al.Anti-Tumor Effect Via Different Sizes of Liposomes Encapsulating Dimethyl Curcumin in Vitro[J].Journal of Changzhou University(Natural Science Edition),2016,(06):14-17.[doi:10.3969/j.issn.2095-0411.2016.06.003]
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脂质体的粒径大小对二甲基姜黄素抗癌能力的影响研究()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2016年06期
页码:
14-17
栏目:
生物医学工程
出版日期:
2016-11-30

文章信息/Info

Title:
Anti-Tumor Effect Via Different Sizes of Liposomes Encapsulating Dimethyl Curcumin in Vitro
作者:
周舒文; 徐德锋; 杨幸群; 马守秀; 戈晓爱; 冯志刚
常州大学 制药与生命科学学院,江苏 常州 213164
Author(s):
ZHOU Shuwen;  XU Defeng;  YANG Xingqun;  MA Shouxiu;  GE Xiaoai;  FENG Zhigang
School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China
关键词:
脂质体;  粒径;  前列腺癌细胞
Keywords:
liposome;  particle size;  prostate cancer cells
分类号:
R 943
DOI:
10.3969/j.issn.2095-0411.2016.06.003
文献标志码:
A
摘要:
为了考察不同粒径的脂质体包裹二甲基姜黄素对前列腺癌细胞增殖活性的影响,采用薄膜分散法制备脂质体,再通过脂质体挤出器得到184、215.3、250.5 nm的脂质体,包药二甲基姜黄素后,进行前列腺癌细胞给药。使用CCK-8细胞增殖活性检测试剂盒检测不同粒径大小的脂质体包裹二甲基姜黄素对前列腺癌细胞的杀伤效果。通过CCK-8测定,得到粒径为184 nm的二甲基姜黄素脂质体对前列腺癌细胞的杀伤力最大,而粒径为250.5 nm的二甲基姜黄素脂质体对前列腺癌细胞的杀伤力较小。在一定范围内包药脂质体粒径对二甲基姜黄素抗癌能力随着粒径减小而增强。
Abstract:
This study is to investigate the anti-cancer ability of liposomes encapsulating Dimethyl curcumin with different sizes in prostate cancer cells. Lipsomes encapsulating Dimethyl curcumin were prepared using the film dispersion technique, then through lipsome extruder and dialysis, 184 nm, 215.3 nm and 250.5 nm lipsomes were obtained for prostate cancer cells administration. The results showed that the liposomes encapsulating Dimethyl curcumin with the size of 184 nm could more efficiently induce the prostate cancer cells death than the liposomes with the size of 250.5 nm. The anti-cancer ability are enhanced with the decrease of particle size.

参考文献/References:

[1]LAI K P, HUANG C K, CHANG Y J, et al.New therapeutic approach to suppress castration-resistant prostate cancer using ASC-J9 via targeting androgen receptor in selective prostate cells [J]. American Journal of Pathology, 2013, 182(2): 460-473.
[2]ANAND P, KUNNUMAKKARA A B, SUNDARAM C,et al. Cancer is a preventable disease that requires major lifestyle changes [J]. Pharmaceutical Research, 2008, 25: 2097-2116.
[3]ANANK P, SUNDARAM C, JHURANI S, et al. Curcumin and cancer: An “old-age” disease with an “age-old” solution [J]. Cancer Letters, 2008, 267: 133-164.
[4]CUI J, ZHAI G X, LOU H X. Research progress of Curcumin [J].Central South Pharmacy, 2005, 3(2):108-111.
[5]DAI H S, SHAN T Y, GAO Y, et al. Extraction of Curcumin from Turmeric and study of its methylating [J]. Nat Prod Res Dev, 2008, 20:254-256.
[6]WEI X, DU Z Y, ZHENG X, et al. Synthesis and evaluation of curcumin-related compounds for anticancer activity [J]. European Journal of Medicinal Chemistry, 2012, 53: 235-245.
[7]SHU F S, CHIUNG-KUEI H, SOO O L, et al. Determination of androgen receptor degradation enhancer ASC-J9 in mouse sera and organs with liquid chromatography tandem mass spectrometry [J]. Journal of Pharmaceutical and Biomedical Analysis, 2014, 88:117-122.
[8]陆彬.药物新剂型与新技术[M].北京:人民卫生出版社,1998:230-232.
[9]平其能.现代药剂学[M].北京:中国医药科技出版社,1995:607-608.
[10]叶兆伟,承伟.脂质体包封率测定方法及影响因素 [J]. 中国生物制品学杂志, 2007, 20(10):789-792.
[11]GOYAL P, GOYAL K, KUMAR S G V, et al, Liposomal drug delivery systems-Clinical applications [J]. Acta Pharm, 2005, 55(1):1-25.
[12]孙维彤,李爱国,张娜,等.论文题目[J].脂质体粒径对促进托氟啶口服吸收的影响.山东大学学报,2007,45(6):640-642.
[13]SUN W T, ZOU W W, HUANG G H, et al. Pharmacokinetics and targeting property of TFu-loaded liposomes with different sizes after intravenous and oral administration [J]. J Drug Target, 2008, 16(5):357-365.
[14]CHIRTHRANI D B, GHAZANI A A, CHAN W C W. Dependence of gold nanoparticle uptake into mammalian cell [J]. Nano Letters, 2006, 6(4):662-668.

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备注/Memo

备注/Memo:
收稿日期:2016-06-05。基金项目:国家自然科学基金资助项目(31271002); 江苏省高校自然科学研究面上项目(14KJB350001)。作者简介:周舒文(1982—),女,江苏常州人,博士,主要从事药物制剂研究。
更新日期/Last Update: 2016-11-20