[1]刘杨,沈欣,任彦,等.柠檬酸改性壳聚糖膜材料的构建及其性能研究[J].常州大学学报(自然科学版),2017,(03):77-82.[doi:10.3969/j.issn.2095-0411.2017.03.011]
　LIU Yang,SHEN Xin,REN Yan,et al.Preparation and Performance of a Chitosan Film Modified by Citric Acid[J].Journal of Changzhou University(Natural Science Edition),2017,(03):77-82.[doi:10.3969/j.issn.2095-0411.2017.03.011]
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柠檬酸改性壳聚糖膜材料的构建及其性能研究()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2017年03期
页码:
77-82
栏目:
生物医学工程
出版日期:
2017-05-28

文章信息/Info

Title:
Preparation and Performance of a Chitosan Film Modified by Citric Acid
作者:
刘杨; 沈欣; 任彦; 顾希茜; 邓林红
常州大学 生物医学工程与健康科学研究院,江苏 常州 213164
Author(s):
LIU Yang;  SHEN Xin;  REN Yan;  GU Xixi;  DENG Linhong
Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China
关键词:
壳聚糖;  柠檬酸;  化学改性;  生物材料
Keywords:
chitosan;  citric acid;  chemical modification;  biomaterials
分类号:
R 318.08
DOI:
10.3969/j.issn.2095-0411.2017.03.011
文献标志码:
A
摘要:
为了改善壳聚糖基材料表面的亲水性和生物相容性,通过引入柠檬酸小分子,分别以EDC和NHS为交联剂和催化剂,对壳聚糖基材料进行了表面化学改性。FTIR和XPS测试结果表明柠檬酸小分子被成功接枝到了壳聚糖膜的表面,材料表面引入的羧基等官能团使得材料表面的亲水性提高。此外,细胞实验结果表明MC3T3成骨细胞能够在改性后的材料表面良好地生长和增殖,证明柠檬酸改性之后的材料具有良好的生物相容性。该材料有可能为骨组织工程支架表面的涂层材料提供一种新选择。
Abstract:
In order to improve the hydrophilicity and biocompatibility of the chitosan-base material, the citric acid was grafted onto the surface of chitosan film by making use of 1-Ethyl-3-(3-dimethyl aminopropyl)carbodiimide(EDC)and N-hydroxysuccinimide(NHS)as the cross-linker in this study. The results of FTIR and XPS test showed that citric acid molecule was successfully grafted onto the surface of the chitosan film. The hydrophilicity of the film was increased due to the introduction of carboxyl functional groups. In addition, the results from cell experiments indicated that the MC3T3 osteoblasts can grow and proliferate well on the surface of the modified material. This chitosan-citric acid film, which can be prepared in large quantities and at low cost, should be applicable potentially in bone tissue engineering.

参考文献/References:

[1] CHANG S H, CHIAN C H. Plasma surface modification effects on biodegradability and protein adsorption properties of chitosan films [J]. Applied Surface Science, 2013, 282: 735-740.
[2]CORDERO-ARIAS L, CABANAS-POLO S, GOUDOURI O M, et al. Electrophoretic deposition of ZnO/alginate and ZnO-bioactive glass/alginate composite coatings for antimicrobial applications [J]. Materials Science and Engineering: C, 2015, 55:137-144.
[3]CHEN S H, ZHENG L Z, XIE X H, et al. Comparative study of poly(lactic-co-glycolic acid)/tricalcium phosphate scaffolds incorporated or coated with osteogenic growth factors for enhancement of bone regeneration [J]. Journal of Orthopaedic Translation, 2014, 2: 91-104.
[4]BALLARRE J, MANJUBALA I, SCHREINER W H, et al. Improving the osteointegration and bone-implant interface by incorporation of bioactive particles in sol-gel coatings of stainless steel implants [J]. Acta Biomaterialia, 2010, 6: 1601-1609.
[5]PISHBIN F, MOURINO V, GILCHRIST J B, et al. Single-step electrochemical deposition of antimicrobial orthopaedic coatings based on a bioactive glass/chitosan/nano-silver composite system [J]. Acta Biomaterialia, 2013, 9:7469-7479.
[6]BELLUCCI D, SOLA A, GENTILE P, et al. Biomimetic coating on bioactive glass-derived scaffolds mimicking bone tissue [J]. Journal of Biomedical Materials Research Part A, 2012, 100A: 3259-3266.
[7]LI Z, DOU H, FU Y, et al. Improving the hydrogen peroxide bleaching efficiency of aspen chemithermomechanical pulp by using chitosan [J]. Carbohydrate Polymers, 2015, 132: 430-436.
[8]GARCIA M A, PEREZ L. Effect of molecular weight reduction by gamma irradiation on chitosan film properties [J]. Materials Science and Engineering: C, 2015, 55: 174-180.
[9]MA X Y, FENG Y F, MA Z S, et al. The promotion of osteointegration under diabetic conditions using chitosan/hydroxyapatite composite coating on porous titanium surfaces [J]. Biomaterials, 2014, 35: 7259-7270.
[10]RAFAT M, LI F, FAGERHOLM P, et al. PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering [J]. Biomaterials, 2008, 29: 3960-3972.
[11]LIN Z, LIU S, SUN X, et al. The effects of citric acid on the synthesis and performance of silver-tin oxide electrical contact materials [J]. Journal of Alloys and Compounds, 2014, 588: 30-35.
[12]SANCHEZ-FERRERO A, MATA á, MATEOS-TIMONEDA M A, et al. Development of tailored and self-mineralizing citric acid-crosslinked hydrogels for in situ bone regeneration [J]. Biomaterials, 2015, 68: 42-53.
[13]WANG X, CHEN J, YAN X, et al. Heavy metal chemical extraction from industrial and municipal mixed sludge by ultrasound-assisted citric acid [J]. Journal of Industrial and Engineering Chemistry, 2015, 27: 368-372.

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备注/Memo

备注/Memo:
收稿日期:2016-06-02。
基金项目:江苏省教育厅自然科学基金面上项目(15KJB310001)。
作者简介:刘杨(1985—),男,湖北仙桃人,博士,讲师,主要从事生物医用材料领域相关研究。
更新日期/Last Update: 2017-06-05