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 ZHOU Xiaoying,JIANG Yuan,WEI Tao.The Function of Mast Cell during Tumor Angiogenesis[J].Journal of Changzhou University(Natural Science Edition),2018,30(05):81-86.[doi:10.3969/j.issn.2095-0411.2018.05.012]





The Function of Mast Cell during Tumor Angiogenesis
周晓鹰12蒋 媛1魏 涛1
1. 常州大学 制药与生命科学学院,江苏 常州 213164; 2. 英国南安普顿大学 医学院,南安普顿 SO16 6YD
ZHOU Xiaoying12 JIANG Yuan1 WEI Tao1
1.School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China; 2.The School of Medicine, University of Southampton, Southampton SO16 6YD, UK
血管新生 肥大细胞 类胰蛋白酶 类糜蛋白酶 肿瘤
angiogenesis mast cell tryptase chymase tumor
R 730.5
The angiogenesis refers to the formation of new blood vessels from pre-existing vascular structures, which is a dynamic process mediated by endothelial cells. This process is highly regulated by the balance between pro-angiogenic and anti-angiogenic factors in the vascular microenvironment, involving extracellular matrix proteins, adhesion molecules and proteolytic enzymes. It plays a crucial role in the cancer genesis, growth and progression of human tumors. Studies indicate that mast cell is the key host cell in the tumor infiltrate, with important consequence on tumor-associated angiogenesis and tumor growth. Activation of Mast cells releases a series of pro-angiogenic factors, in which the specific proteases, tryptase and chymase, play an important role in mediating angiogenesis and promoting tumor development. This review clarifies the biological characteristics of mast cell and the relationship between its specific proteases and angiogenesis, which provides a new therapeutic perspective for tumor angiogenesis.


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[4]周晓鹰,魏 涛.哮喘疾病中肥大细胞与气道平滑肌细胞的相互作用[J].常州大学学报(自然科学版),2018,30(04):87.[doi:10.3969/j.issn.2095-0411.2018.04.014]
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基金项目:常州大学高层次人才引进启动基金(ZMF14020066); 常州科技局国际交流研究基金(CZ20150014); 英国British Medical Research Council, UK(G0500729)。
更新日期/Last Update: 2018-09-28