[1]单学凌,杨天宇,殷嘉豪,等.RuSiNPs/SnO2复合膜修饰电极用于沙丁胺醇的检测[J].常州大学学报(自然科学版),2020,32(01):22-30.[doi:10.3969/j.issn.2095-0411.2020.01.004]
　SHAN Xueling,YANG Tianyu,YIN Jiahao,et al.Research on Detection of Salbutamol Using RuSiNPs/SnO2 Complex Modified GCE[J].Journal of Changzhou University(Natural Science Edition),2020,32(01):22-30.[doi:10.3969/j.issn.2095-0411.2020.01.004]
点击复制

RuSiNPs/SnO2复合膜修饰电极用于沙丁胺醇的检测()
分享到：

常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
第32卷
期数:
2020年01期
页码:
22-30
栏目:
化学化工
出版日期:
2020-01-28

文章信息/Info

Title:
Research on Detection of Salbutamol Using RuSiNPs/SnO2 Complex Modified GCE
文章编号:
2095-0411(2020)01-0022-09
作者:
单学凌1; 杨天宇2; 殷嘉豪1; 潘瑜婷1; 陈智栋1
(1.常州大学 石油化工学院,江苏 常州213164; 2.常州大学 国际教育交流学院,江苏 常州 213164)
Author(s):
SHAN Xueling1;  YANG Tianyu2;  YIN Jiahao1;  PAN Yuting1;  CHEN Zhidong1
(1.School of Petrochemical Engineering,Changzhou University,Changzhou 213164,China; 2. School of International Education and Exchange, Changzhou University,Changzhou 213164,China )
关键词:
电化学发光;  钌硅纳米粒子;  氧化锡;  沙丁胺醇;  高灵敏度
Keywords:
electrochemiluminescence;  RuSiNPs;  SnO2;  salbutamol;  high sensitivity
分类号:
O 657.12
DOI:
10.3969/j.issn.2095-0411.2020.01.004
文献标志码:
A
摘要:
采用一步法制得三联吡啶钌(Ru(bpy)2+3)复合的二氧化硅(SiO2)纳米粒子(RuSiNPs),并将其与氧化锡(SnO2)共同修饰在玻碳电极(GCE)表面,构建了一种高灵敏度的增敏型电化学发光(ECL)传感器,并将其应用于沙丁胺醇测定的研究。当一定量的沙丁胺醇加入到电解液之中后,ECL强度得到加强,且当沙丁胺醇浓度在10～5.0×104 nmol·L-1范围内时,增加的ECL强度与沙丁胺醇浓度的对数呈现很好的线性关系,检测限为3.2 nmol·L-1(S/N=3)。此方法在应用到实际样品中沙丁胺醇含量的测定时,具有很好的抗干扰能力,增加了电化学发光法在现实领域的应用潜力。
Abstract:
The Ru(bpy)2+3 immobilized SiO2 nanoparticles(RuSiNPs)were successfully prepared through a one-step reaction. After that, the RuSiNPs and SnO2 were co-modified on GCE surface to construct a highly sensitive electrochemiluminescence(ECL)sensor for salbutamol. When a certain amount of salbutamol was present in the electrolyte, the ECL intensity was enhanced and showed a good correlation to salbutamol concentration in the range 10—5.0×104 nmol·L-1, with a detection limit of 3.2 nmol·L-1(S/N=3). Furthermore, the proposed ECL sensor exhibited an excellent anti-interference ability when it was applied for salbutamol detection in real samples. It significantly increased the application potential of ECL method in real-world.

参考文献/References:

[1]罗宿星, 黄丽娟, 伍远辉. 肉制品中瘦肉精的检测方法[J]. 遵义师范学院学报, 2014, 16(6): 74-77.
[2]来利利. 硫酸沙丁胺醇联合布地奈德治疗婴幼儿毛细支气管炎疗效观察[J]. 中国药物与临床, 2013, 13(S1): 41-42.
[3]宁霄, 金绍明, 梁瑞强, 等. 超高效液相色谱-串联质谱法测定猪肉中β-受体激动剂残留量的不确定度分析[J]. 食品科学, 2017,38(6): 321-326.
[4]CHANG K C, CHANG Y T, TSAI C E. Determination of ractopamine and salbutamol in pig hair by liquid chromatography tandem mass spectrometry[J]. Journal of Food and Drug Analysis, 2018, 26(2): 725-730.
[5]XIAO Y P, LU H Y, LYU S J, et al. Rapid analysis of trace salbutamol and clenbuterol in pork samples by mass spectrometry[J]. Chinese Journal of Analytical Chemistry, 2016, 44(11): 1633-1638.
[6]DE MARÍA L A O, OLSINA R A, MASI A N. Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide(TOPO)as coligand[J]. Analyst, 2005, 130(9): 1312-1317.
[7]LEI Y J, YAO X Y, ZHANG D, et al. Investigation of the salbutamol residue level in human urinary samples by a sensitive direct competitive ELISA[J]. Analytical Methods, 2015, 7: 5635-5640.
[8]GOYAL R N, KAUR D, SINGH S P, et al. Effect of graphite and metallic impurities of C60 fullerene on determination of salbutamol in biological fluids[J]. Talanta, 2008, 75(1): 63-69.
[9]GOYAL R N, OYAMA M, SINGH S P. Fast determination of salbutamol, abused by athletes for doping, in pharmaceuticals and human biological fluids by square wave voltammetry[J]. Journal of Electroanalytical Chemistry, 2007, 611(1/2): 140-148.
[10]TOKEL N E, BARD A J. Electrogenerated chemiluminescence. IX. electrochemistry and emission from systems containing tris(2,2'-bipyridine)ruthenium(II)dichloride[J]. Journal of the American Chemical Society, 1972, 94(8): 2862-2863.
[11]LI L, YU B, ZHANG X, et al. A novel electrochemiluminescence sensor based on [formula omitted] carbon nanodots system for the detection of bisphenol A[J]. Analytica Chimica Acta, 2015, 895(37): 104-111.
[12]MAO L, YUAN R, CHAI Y, et al. A new electrochemiluminescence immunosensor based on Ru(bpy)2+3-doped TiO2 nanoparticles labeling for ultrasensitive detection of human chorionic gonadotrophin[J]. Sensors and Actuators: B Chemical, 2010, 149(1): 226-232.
[13]HOSSEINI M, PUR K R M, NOROUZI P, et al. An enhanced electrochemiluminescence sensor modified with a Ru(bpy)2+3/Yb2O3 nanoparticle/nafion composite for the analysis of methadone samples[J]. Materials Science and Engineering: C, 2017, 76: 483-489.
[14]LYU X, LI Y, YAN T, et al. Electrochemiluminescence modified electrodes based on RuSi@Ru(bpy)2+3 loaded with gold functioned nanoporous CO/Co3O4 for detection of mycotoxin deoxynivalenol[J]. Biosensors and Bioelectronics, 2015, 70: 28-33.
[15]BOZORGZADEH S, HAGHIGHI B, GORTON L. Fabrication of a highly efficient solid state electrochemiluminescence sensor using Ru(bpy)2+3 incorporated nanoZnO-MWCNTs-Nafion composite film[J]. Electrochimica Acta, 2015, 164: 211-217.
[16]ZHENG L, WANG B, CHI Y, et al. Using stannous ion as an excellent inorganic ECL coreactant for tris(2,2'-bipyridyl)ruthenium(II)[J]. Dalton Trans, 2012, 41(5): 1630-1634.
[17]ZHENG L, CHI Y, WANG B, et al. Strong electrochemiluminescence based on electron transfer between tris(2,2'-bipyridine)ruthenium(III)and SnO NPs@MWCNTs[J]. Chemical Communications, 2010, 46(31): 5734-5736.
[18]LIU F Y, YANG X, ZHAO Y Q, et al. Detection of malachite green and leucomalachite green based on electrochemiluminescence of mono- and bimetallic ruthenium tris-bipyridyl complexes at an Au electrode[J]. Analytical Methods, 2013, 5(3): 660-665.
[19]CAI C, CHENG H, WANG Y, et al. Simultaneous determination of four β2-agonist residues in pig feed and urine by capillary electrophoresis with field amplified sample injection and electrochemiluminescent detection[J]. Analytical Methods, 2013, 5(19): 4978-4983.
[20]陈玉婷,郭伟,孙贤祥,等. 硫酸沙丁胺醇溶解度的实验测定与预测[J]. 常州大学学报(自然科学版),2010,22(3):74-78.
[21]KARUWAN C,WISITSORAAT A,MATUROS T,et al. Flow injection based microfluidic device with carbon nanotube electrode for rapid salbutamol detection[J].Talanta,2009,79(4):995-1000.
[22]LIU S,LIN Q,ZHANG X,et al. Electrochemical immunosensor for salbutamol detection based on CS-Fe3O4-PAMAM-GNPs nanocomposites and HRP-MWCNTs-Ab bioconjugates for signal amplification[J].Sensors and Actuators B:Chemical,2011,156(1):71-78.

备注/Memo

备注/Memo:
收稿日期:2019-09-30。
基金项目:江苏省高校自然科学研究资助项目(18KJB150001)。
作者简介:单学凌(1988—),男,江苏盐城人,博士,讲师。通信联系人:陈智栋(1964—),E-mail: zdchen@cczu.edu.cn
更新日期/Last Update: 2020-01-13