[1]赵 帅,陈湘香,金 雷,等.不对称亲核催化合成手性芳基烯丙基醚类化合物[J].常州大学学报(自然科学版),2020,32(05):27-34.[doi:10.3969/j.issn.2095-0411.2020.05.004]
 ZHAO Shuai,CHEN Xiangxiang,JIN Lei,et al.Asymmetric Synthesis of Chiral Aryl Allyl Ethers by Nucleophilic Catalysis[J].Journal of Changzhou University(Natural Science Edition),2020,32(05):27-34.[doi:10.3969/j.issn.2095-0411.2020.05.004]
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不对称亲核催化合成手性芳基烯丙基醚类化合物()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
第32卷
期数:
2020年05期
页码:
27-34
栏目:
化学化工
出版日期:
2020-09-28

文章信息/Info

Title:
Asymmetric Synthesis of Chiral Aryl Allyl Ethers by Nucleophilic Catalysis
文章编号:
2095-0411(2020)05-0027-08
作者:
赵 帅陈湘香金 雷陈至立陈 新
常州大学 制药与生命科学学院,江苏 常州 213164
Author(s):
ZHAO Shuai CHEN Xiangxiang JIN Lei CHEN Zhili CHEN Xin
School of Pharmaceutical Engineering & Life Sciences, Changzhou University, Changzhou 213164, China
关键词:
亲核催化 脱CO2 手性芳基烯丙基醚
Keywords:
nucleophilic catalysis CO2 releasing chiral aryl allyl ether
分类号:
O 625.3
DOI:
10.3969/j.issn.2095-0411.2020.05.004
文献标志码:
A
摘要:
手性芳基烯丙基醚类化合物是一类重要的结构骨架,其广泛存在于天然产物和药物活性分子结构中。以设计合成的MBH(Morita-Baylis-Hillman)碳酸苯酯作为反应底物,其在亲核手性催化剂作用下脱去一分子CO2,生成了一系列含有各种取代基的手性的芳基烯丙基醚化合物。产率高达95%,对映选择性高达90%。产物结构经1H NMR和13C NMR鉴定正确。
Abstract:
Chiral aryl allyl ethers are important substructure which can be found in a lot of natural products and bioactive molecules. A series of substituted chiral aryl allyl ethers were successfully synthesized from the newly designed MBH carbonates by releasing a molecule of CO2 under nucleophilic catalysis. The yields are up to 95% and the enantioselectivities are up to 90%. The structure of products was determined by 1H NMR and 13C NMR.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2020-04-05。
基金项目:国家自然科学基金资助项目(21602018)。
作者简介:赵帅(1988—),男,河南开封人,博士,讲师。通信联系人:陈新(1965—),E-mail:xinchen@cczu.edu.cn
更新日期/Last Update: 2020-09-20