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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:

期数:

2000年04期

页码:

20-22

栏目:

出版日期:

2000-12-25

文章信息/Info

Title:

Synthesis and Character ization of Allantoin

作者:

李桂云;  马江权

江苏石油化工学院化学工程系, 江苏 常州 213016

Author(s):

LI Gui -yun ;  MA Jiang -quan

Department of Chemical Engineering , Jiangsu Insti tute of Petrochemical Technolog y , Changzhou 213016 , China

关键词:

尿囊素; 乙醛酸; 尿素; 合成

Keywords:

allantoin ; glyoxylic acid ; urea ; sy nthesis

分类号:

O 626.23 ;T Q 252.3

文献标志码:

A

摘要:

采用硝硫混酸作催化剂, 乙醛酸(乙二醛硝酸氧化法, 未分离) 和尿素为原料缩合反应合成了尿囊素。考察了原料配 比、反应温度和反应时间以及催化剂的组成和用量对尿囊素产率的影响。得到适宜的工艺条件为:尿素与乙醛酸物质的量比为 5∶1 , 硫酸与硝酸物质的量比为8∶1 , 混酸与乙醛酸物质的量比为0.5∶1 , 反应温度为75 ℃, 反应时间为3 h 。在上述工艺条件 下, 尿囊素的产率达到59.3 %, 产品纯度达到98.5 %以上。并通过熔点测定、元素分析和IR 光谱对产品进行了验证。

Abstract:

Allantoin acid was produced by condensating glyoxylic acid (prepared by means of oxidation glyoxal with nitric acid , without separation)w ith urea in the presence of nit ro -sulfuric acid catalyst .The influences of the molar ratio of urea to glyo xylic acid , reaction temperature , react ion time , the quantity and composition of catalyst on the yield of product were investigated .The optimum synthetic conditions were urea/glyoxylic acid molar ratio 5∶1 , sulfuric acid/ni tric acid molar ratio 8∶1 , nitro -sulfuric acid catalyst/gly oxylic acid molar ratio 0.5∶1 , reaction t ime 3 h and reaction temperature 75 ℃.Under the optimum conditions , the yield of allantoin w as 59.3 %, the purity of allantoin over 98.5 %.Through melting test , elementary analysis and spect rum of IR , the constitutional fo rmula of allantoin was proved

备注/Memo

备注/Memo:

作者简介:李桂云(1950 -), 女, 河北卢龙人, 实验师。

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更新日期/Last Update: 2000-12-25