[1]石 磊,柴 文,席海涛,等.4-溴-5-硝基-1H-吡咯-2-甲酸乙酯合成方法改进[J].常州大学学报(自然科学版),2011,(03):13-16.
　SHI Lei,CHAI Wen,XI Hai-tao,et al.Improvement in the Syntheic Method of 4-Bromo-5-Nitro-1H- Pyrrole-2-Carboxylic Acid Ethyl Ester[J].Journal of Changzhou University(Natural Science Edition),2011,(03):13-16.
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4-溴-5-硝基-1H-吡咯-2-甲酸乙酯合成方法改进()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2011年03期
页码:
13-16
栏目:
出版日期:
2011-06-30

文章信息/Info

Title:
Improvement in the Syntheic Method of 4-Bromo-5-Nitro-1H- Pyrrole-2-Carboxylic Acid Ethyl Ester
作者:
石 磊1; 柴 文2; 席海涛1; 孙小强1; 袁荣鑫2
(1.常州大学 石油化工学院,江苏 常州 213164; 2.常熟理工学院,江苏 常熟 215500)
Author(s):
SHI Lei1; CHAI Wen2; XI Hai-tao1; SUN Xiao-qiang1; YUAN Rong-xin2
School of Petrochemical Engineering,Changzhou University,Changzhou 213164,China; 2.Changshu Institute of Technologhy,Changshu 215500,China)
关键词:
吡咯;  溴化;  4-溴-5-硝基-1H-吡咯-2-甲酸乙酯
Keywords:
pyrrole;  bromation;  ethyl 4-bromo-5-nitro-1H-pyrrole-2-carboxylate
分类号:
O 626
文献标志码:
A
摘要:
以吡咯为原料经酰基化、NBS为溴化、乙醇钠亲核取代、发烟硝酸硝化,以64.3%的总收率合成目标化合物4-溴-5-硝基-1H-吡咯-2-甲酸乙酯,合成工艺适合工业化生产,目标化合物的结构经1H NMR、MS等表征。
Abstract:
Using the pyrrole as the starting material, ethyl 4-bromo-5-nitro-1H-pyrrole-2-carboxylate was synthesized through acylation, bromation by NBS, nucleophilic substitution by NaOC2H5 and nitration by fuming nitric acid. The total yield of the target product was 64.3%, and the synthetic technique is suitable for industrial production. The target product structure was characterized by 1H NMR, MS spectra, etc.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:石磊(1985-),男,江苏连云港人,硕士; 通讯联系人:席海涛。
更新日期/Last Update: 2011-06-30