[1]吴玉成,徐腾,林富荣,等.3-氨基-3-(4-氯苯基)丙酸的合成工艺研究[J].常州大学学报(自然科学版),2014,(01):28-31.[doi:10.3969/j.issn.2095-0411.2014.01.007]
　WU Yu-cheng,XU Teng,LIN Fu-rong.Study on the Synthesis Process of 3Amino3 (4Chlorophenyl)Propionic Acid[J].Journal of Changzhou University(Natural Science Edition),2014,(01):28-31.[doi:10.3969/j.issn.2095-0411.2014.01.007]
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3-氨基-3-(4-氯苯基)丙酸的合成工艺研究()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2014年01期
页码:
28-31
栏目:
化学化工
出版日期:
2014-02-28

文章信息/Info

Title:
Study on the Synthesis Process of 3Amino3 (4Chlorophenyl)Propionic Acid
作者:
吴玉成；徐腾；林富荣；
常州大学 江苏省精细石油化工重点实验室,江苏 常州 213164
Author(s):
WU Yu-cheng;  XU Teng;  LIN Fu-rong
Jiangsu Key Laboratory of Fine Petrochemical Engineering,Changzhou University,Changzhou 213164,China
关键词:
3氨基3(4氯苯基)丙酸;  4氯苯甲醛;  氨气
Keywords:
3amino3(4chlorophenyl)propionic acid;  4chlorobenzaldehyde;  ammonia
分类号:
TQ245.3
DOI:
10.3969/j.issn.2095-0411.2014.01.007
文献标志码:
A
摘要:
以4氯苯甲醛、丙二酸为起始原料,以氨气为氨化剂在高压釜内反应得目标产物3氨基3(4氯苯基)丙酸。研究了工艺条件对反应的影响。其适宜的合成工艺条件:在反应温度95 ℃,氨气压力控制在0.6～0.8 MPa下,选用乙醇为溶剂,哌啶为催化剂,催化剂用量为5%(质量分数),4氯苯甲醛和丙二酸的物质的量比为1:1.4,反应10 h,收率可达79.4%,产品熔点为222.5～222.7 ℃。该方法以氨气为氨化剂不仅原料成本比乙酸铵低,而且产品纯度也更高,更容易实现大规模工业化生产。
Abstract:
3amino3(4chlorophenyl)propionic acid was prepared in autoclave using 4chlorobenzaldehyde and malonic acid as raw materials, and ammonia as ammoniating agent. The effect of reaction conditions on reaction was studied. It has been shown that the yield of 3amino3(4chlorophenyl)propionic acid can be up to 79.4% under reaction temperature 95 ℃, reaction time 10h and the molar ratio of 4chlorobenzaldehyde to malonic acid being 1:1.4, using ethanol as solvent, piperidine as catalyst, the amount of catalyst being 5%, ammonia pressure in the range of 0.6～0.8 MPa, the melting point of product is 222.5～222.7 ℃. The cost of ammonia as ammoniating agent in this method is lower than ammonium acetate, and the purity of the product is also higher, so it is easy to implement largescale industrial production.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:吴玉成(1989-),男,江苏南京人,硕士生; 通讯联系人:林富荣。
更新日期/Last Update: 2014-02-20