[1]李正义,王鹏飞,殷晓伟,等.核磁共振技术在氨基糖苷类抗生素结构研究中的应用[J].常州大学学报(自然科学版),2017,(01):50-55.[doi:doi:10.3969/j.issn.2095-0411.2017.01.009]
　LI Zhengyi,WANG Pengfei,YIN Xiaowei,et al.The Application of NMR Technology in Structural Research of Aminoglycoside Antibiotics[J].Journal of Changzhou University(Natural Science Edition),2017,(01):50-55.[doi:doi:10.3969/j.issn.2095-0411.2017.01.009]
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核磁共振技术在氨基糖苷类抗生素结构研究中的应用()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2017年01期
页码:
50-55
栏目:
生物医学工程
出版日期:
2017-01-28

文章信息/Info

Title:
The Application of NMR Technology in Structural Research of Aminoglycoside Antibiotics
作者:
李正义1; 王鹏飞1; 殷晓伟2; 晏培培1; 邵丹迪1; 殷乐1; 孙小强1
1. 常州大学 石油化工学院,江苏 常州213164; 2. 常州方圆制药有限公司,江苏 常州213022
Author(s):
LI Zhengyi1;  WANG Pengfei1;  YIN Xiaowei2;  YAN Peipei1;  SHAO Dandi1;  YIN Yue1;  SUN Xiaoqiang1
1. School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China; 2. Changzhou Fangyuan Pharmaceutical Co.,Ltd.,Changzhou 213022, China
关键词:
核磁共振技术;  氨基糖苷类抗生素;  依替米星;  庆大霉素;  结构鉴定
Keywords:
NMR technology;  aminoglycoside antibiotics;  etimicin;  gentamicin;  structural identification
分类号:
R 917
DOI:
doi:10.3969/j.issn.2095-0411.2017.01.009
文献标志码:
A
摘要:
综合运用1H NMR、13C NMR、DEPT、1H-1H COSY、HSQC和HMBC一维和二维核磁共振技术,详细对比研究了依替米星、1,3-二-N-乙基庆大霉素C1a和1,6’-二-N-乙基庆大霉素C1a的结构特点,尤其是乙基所处不同氨基位点对于邻近碳氢化学位移的影响,建立了一种快速、准确分析氨基糖苷类抗生素结构的方法。
Abstract:
The structure characteristics of ETM, 1,3-di-N-ethyl GMC1a and 1,6’-di-N-ethyl GMC1a have been comparatively studied in detail by means of 1D and 2D NMR technologies including 1H NMR, 13C NMR, DEPT, 1H-1H COSY, HSQC and HMBC. In particular, the effects on the chemical shift of neighboring carbon and hydrogen influenced by ethyl group located on different amino groups were investigated. A rapidly and accurately structural analysis method for aminoglycoside antibiotics was established.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2016-06-08。
基金项目:国家自然科学基金资助项目(21572026); 江苏省高校自然科学研究重大项目(14KJA150002); 江苏省先进催化与绿色制造协同创新中心资助项目(ACGM2016-06-05)。
作者简介:李正义(1979—),男,江苏扬州人,博士,副教授,主要从事有机化学研究。通讯联系人:孙小强(1956—),E-mail: sunxiaoqiang@yahoo.com
更新日期/Last Update: 2017-02-10