[1]王克敏,朱奇凡,俞强.低温光聚合制备可降解多孔支架及其性能[J].常州大学学报(自然科学版),2017,(05):35-45.[doi:10.3969/j.issn.2095-0411.2017.05.006]
 WANG Kemin,ZHU Qifan,YU Qiang.Preparation and Properties of Biodegradable Crosslinking Porous Scaffolds Materials via Low Temperature Phase Separation Photopolymerization[J].Journal of Changzhou University(Natural Science Edition),2017,(05):35-45.[doi:10.3969/j.issn.2095-0411.2017.05.006]
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低温光聚合制备可降解多孔支架及其性能()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2017年05期
页码:
35-45
栏目:
材料科学与工程
出版日期:
2017-09-30

文章信息/Info

Title:
Preparation and Properties of Biodegradable Crosslinking Porous Scaffolds Materials via Low Temperature Phase Separation Photopolymerization
作者:
王克敏朱奇凡俞强
常州大学 材料科学与工程学院,江苏 常州 213164
Author(s):
WANG Kemin ZHU Qifan YU Qiang
School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China
关键词:
聚乳酸 聚己内酯 低温光聚合 多孔支架
Keywords:
polylactic acid polycaprolactone low temperature photopolymerization porous scaffold
分类号:
TQ 316
DOI:
10.3969/j.issn.2095-0411.2017.05.006
文献标志码:
A
摘要:
以聚己内酯二醇和聚乳酸二醇为原料,合成了端双键的聚己内酯二甲基丙烯酸酯(PCLDMA)和聚乳酸二丙甲基烯酸酯(PLADMA)。通过低温光聚合诱导相分离制备可降解多孔支架。结果表明:溶剂含量越高,孔隙率越高,孔径尺寸也越大; 冷却温度对孔隙率的影响不大,但孔的尺寸随着冷却温度的降低逐渐减小,冷却速率越快,孔隙率和孔径尺寸越小; PCLDMA的热稳定性高于PLADMA,多孔支架孔隙率越大溶胀度越大; 两种材料在PBS溶液中较为稳定,体外降解缓慢; PLADMA支架抗压强度和弹性模量高,性脆; PCLDMA支架抗压强度和弹性模量低,但韧性好。
Abstract:
The double bond-terminated polycaprolactone dimethacrylate(PCLDMA)and the double-capped polylactic acid dipropyl methacrylate(PLADMA)were synthesized. The biodegradable porous scaffolds were prepared by low temperature photopolymerization induced phase separation. The results of scanning electron microscopy showed the higher the solvent content, the higher the porosity and the larger the pore size. The size of the pores decreases gradually as the cooling temperature decreases, the faster the cooling rate, the smaller the porosity and pore size. The thermal stability of PCLDMA porous scaffold was higher than that of PLADMA. Two kinds of materials in PBS solution were stable and slow degradation in vitro. The mechanical properties of PLADMA porous scaffold have high compressive strength and elastic modulus, and the brittleness of PCLDMA scaffold has low compressive strength and elastic modulus, but possessed good toughness and some deformation recovery.

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备注/Memo

备注/Memo:
收稿日期:2017-04-21。 基金项目:国家自然科学基金资助项目(21304011)。 作者简介:王克敏(1979—),男,湖北天门人,博士,讲师,主要从事生物材料研究。E-mail:wangkemin@cczu.edu.cn
更新日期/Last Update: 2017-10-20