[1]刘杨,张中勋,伍铭慧,等.氧化石墨烯修饰壳聚糖基支架的构建及其作为骨修复材料的研究[J].常州大学学报(自然科学版),2018,30(01):87-92.[doi:10.3969/j.issn.2095-0411.2018.01.014]
　LIU Yang,ZHANG Zhongxun,WU Minghui,et al.Preparation of Chitosan Scaffold Modified by Graphene Oxide and Its Potential Applications as Bone Repair Material[J].Journal of Changzhou University(Natural Science Edition),2018,30(01):87-92.[doi:10.3969/j.issn.2095-0411.2018.01.014]
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氧化石墨烯修饰壳聚糖基支架的构建及其作为骨修复材料的研究()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
第30卷
期数:
2018年01期
页码:
87-92
栏目:
生物医学工程
出版日期:
2018-01-28

文章信息/Info

Title:
Preparation of Chitosan Scaffold Modified by Graphene Oxide and Its Potential Applications as Bone Repair Material
作者:
刘杨; 张中勋; 伍铭慧; 秦勇; 邓林红
常州大学 生物医学工程与健康科学研究院,江苏 常州 213164
Author(s):
LIU Yang;  ZHANG Zhongxun;  WU Minghui;  QIN Yong;  DENG Linhong
Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou 213164, China
关键词:
壳聚糖;  氧化石墨烯;  骨修复;  生物材料
Keywords:
chitosan;  graphene oxide;  bone repair;  biomaterials
分类号:
R 318.08
DOI:
10.3969/j.issn.2095-0411.2018.01.014
文献标志码:
A
摘要:
为提高壳聚糖基支架材料的力学性能,尝试通过引入氧化石墨烯分子对壳聚糖基支架材料进行了化学修饰(GO/CS),并对改性前后的壳聚糖基支架材料的微观结构、理化性能和生物学性能进行了评价。FTIR分析表明氧化石墨烯与壳聚糖分子发生了有效的接枝。SEM照片显示GO/CS材料内部具有均一的三维多孔结构,孔洞尺寸分布在数十微米且相互连通。改性之后的材料具有较好的保湿性能和高孔隙率。相对于纯壳聚糖支架,材料的力学性能显著提升。此外,细胞实验结果还表明氧化石墨烯改性之后的材料具有良好的生物相容性。本研究获得的氧化石墨烯改性壳聚糖支架有可能为骨组织工程材料提供一种新选择。
Abstract:
In order to improve the mechanical properties of the chitosan-based scaffold, the grapheme oxide was introduced into the chitosan scaffold through chemical modification by making use of 1-Ethyl-3-(3-dimethyl aminopropyl)carbodiimide(EDC)and N-hydroxysuccinimide(NHS)as the cross-linker in this study. Micro-structure, physicochemical properties and biocompatibility of the grapheme oxide modified chitosan scaffolds(GO/CS)were characterized. The results of fourier transform infrared spectroscopy(FTIR)test show that the grapheme oxide was crosslinked with chitosan molecular successfully. SEM photos indicate that the GO/CS scaffold has a uniform three-dimensional porous structure. Compared with the pure chitosan scaffold, mechanical performance of the GO/CS scaffold significantly increased. In addition, the cell experimental results indicate that the MC3T3 osteoblasts can grow and proliferate well in the GO/CS scaffold. This grapheme oxide modified chitosan scaffold, which can be prepared in large quantities and at low cost, should have potential application in bone tissue engineering.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2017-09-10。
基金项目:江苏省科技厅自然科学基金面上项目(BK20171196); 江苏省教育厅自然科学基金面上项目(15KJB310001)。
作者简介:刘杨(1985—),男,湖北仙桃人,博士,讲师。E-mail: liuyang@cczu.edu.cn
更新日期/Last Update: 2018-02-20