[1]钱明成,江欣育,戚颖,等.苦参碱新类似物的合成和抗肿瘤活性研究[J].常州大学学报(自然科学版),2022,34(02):81-86.[doi:10.3969/j.issn.2095-0411.2022.02.010]
　QIAN Mingcheng,JIANG Xinyu,QI Ying,et al.Synthesis of Novel Analogues of Matrine and Anti-Tumor Activity Assessment[J].Journal of Changzhou University(Natural Science Edition),2022,34(02):81-86.[doi:10.3969/j.issn.2095-0411.2022.02.010]
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苦参碱新类似物的合成和抗肿瘤活性研究()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
第34卷
期数:
2022年02期
页码:
81-86
栏目:
生物医药工程
出版日期:
2022-03-28

文章信息/Info

Title:
Synthesis of Novel Analogues of Matrine and Anti-Tumor Activity Assessment
文章编号:
2095-0411(2022)02-0081-06
作者:
钱明成; 江欣育; 戚颖; 刘慧敏; 周阔; 赵帅; 陈新
(常州大学药学院,江苏常州213164)
Author(s):
QIAN Mingcheng;  JIANG Xinyu;  QI Ying;  LIU Huimin;  ZHOU Kuo;  ZHAO Shuai;  CHEN Xin
(School of Pharmacy, Changzhou University, Changzhou 213164, China)
关键词:
苦参碱;  构效关系;  抗肿瘤
Keywords:
matrine;  structure activity relationship;  anti-tumor activity
分类号:
R 9
DOI:
10.3969/j.issn.2095-0411.2022.02.010
文献标志码:
A
摘要:
合成了一系列苦参碱分子内酰胺部分开环的新类似物。体外细胞毒性研究表明,结构中含有萘环和苯甲酰基类似物的化合物C4,与其母体化合物苦参碱及其他内酰胺开环类似物相比,具有最佳的抗增殖活性。综上,文章发现了一个潜在的抗肿瘤先导化合物C4,该化合物可用于进一步的体内外抗肿瘤研究。
Abstract:
In this article, a series of matrine analogues with ring-opening in the lactam portion of the molecule were synthesized and assessed against four cancer cell lines. The in vitro cytotoxicity study exhibited that analogue C4 with a naphthyl ring displayed the best antiproliferative activity compared to its parent compound matrine and other lactam ring-opening analogues. Taken together, the anti-tumor potential lead compound C4 was discovered, which could be used for further study.

参考文献/References:

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(责任编辑:李艳,周安迪)

备注/Memo

备注/Memo:
收稿日期: 2021-10-29。
作者简介: 钱明成(1988—), 男, 江苏沭阳人, 博士, 讲师。通信联系人: 陈新(1965—), E-mail: xinchen@cczu.edu.cn
引用本文: QIAN M C, JIANG X Y, QI Y, et al. Synthesis of Novel Analogues of Matrine and Anti-Tumor Activity Assessment[J]. 常州大学学报(自然科学版), 2022, 34(2):
更新日期/Last Update: 1900-01-01