[1]华玉婷,杨 程,张 青,等.光热-磁控双响应量子点复合纳米载药粒子的合成与应用[J].常州大学学报(自然科学版),2023,35(02):17-25.[doi:10.3969/j.issn.2095-0411.2023.02.003 ]
　HUA Yuting,YANG Cheng,ZHANG Qing,et al.Synthesis and application of photothermal-magnetic dual response quantum dot composite nanometer as drug-loaded particles[J].Journal of Changzhou University(Natural Science Edition),2023,35(02):17-25.[doi:10.3969/j.issn.2095-0411.2023.02.003 ]
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光热-磁控双响应量子点复合纳米载药粒子的合成与应用 ()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
第35卷
期数:
2023年02期
页码:
17-25
栏目:
化学化工
出版日期:
2023-03-28

文章信息/Info

Title:
Synthesis and application of photothermal-magnetic dual response quantum dot composite nanometer as drug-loaded particles
文章编号:
2095-0411(2023)02-0017-09
作者:
华玉婷;  杨 程;  张 青;  石绍明;  毛辉麾;  王美阳;  左士祥;  姚 超
(常州大学 石油化工学院, 江苏 常州 213164)
Author(s):
HUA Yuting;  YANG Cheng;  ZHANG Qing;  SHI Shaoming;  MAO Huihui;  WANG Meiyang;  ZUO Shixiang;  YAO Chao
(School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China)
关键词:
介孔二氧化硅;  负载;  磁性材料;  纳米分子筛;  药物释放
Keywords:
mesoporous silica;  loading;  magnetic material;  nano molecular sieve;  drug release
分类号:
TQ 645.6
DOI:
10.3969/j.issn.2095-0411.2023.02.003
文献标志码:
A
摘要:
结合纳米Fe3O4,介孔二氧化硅和石墨相氮化碳量子点的特征,制备了一种具备核壳结构,磁性和光热控制双响应的药物释放纳米载体材料Fe3O4@SiO2-NH2@g-C3N4(QD)。核为纳米Fe3O4,介孔二氧化硅壳层(SiO2)为药物提供装载空间,材料内表面上有机碳链和胺基起到吸附药物和封堵孔道的作用。在磁性作用下,药物载体能够保持极低的释放量。红外光热作用使载体温度上升,药物有效成分快速释放。通过X射线衍射、透射电镜、红外光谱、N2等温吸脱附、VSM磁强度测试和Zeta电位分析测试材料的相关性能,并通过体外释放实验研究药物,检测可控释放的效果。结果表明:pH调节,磁场作用,红外光照射的条件下,都可以有效调节药物释放的速率,而温度也对药物释放的速率起到了一定的协同作用,并在磁场作用下起到开关(on-off)释放作用。
Abstract:
In this study, combining the characteristics of nano-Fe3O4, mesoporous silica, and graphite phase carbon nitride quantum dots, a core-shell nano-carrier material Fe3O4@SiO2-NH2@g-C3N4 with a dual response of magnetic and photothermal control for drug release was synthesized. The mesoporous silica shell(SiO2)provides a loading space for the drug, and the organic carbon chain and amino groups on the inner surface of the material play the role of adsorbing the drug and blocking the pores. In the magnetic field, the drug carrier can maintain a very low release amount. When the temperature of the carrier was increased by photothermal action, the active ingredient of the drug released quickly.The X-ray diffraction, transmission electron microscopy, infrared spectroscopy, N2 isothermal absorption and desorption, VSM magnetic intensity and Zeta potential analysi were employed to characterized the relevant properties of the materials. And the effect of controlled drug release was analyzed by in vitro release experiments. The results show that pH regulation, magnetic field and infrared light can effectively regulate the release rate of drugs, and the temperature also plays a synergistic role in the release rate of drugs, and plays an on-off switch release role in the magnetic field.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2022-12-10。
作者简介: 华玉婷(1997—), 女, 四川眉山人, 硕士生。 通信联系人: 毛辉麾(1981—), E-mail: maohuihui_beijing@126.com

更新日期/Last Update: 1900-01-01