[1]胡航,肖文,陶亚宇,等.负载新吲哚菁绿的还原响应性聚合物胶束增强肿瘤光动力治疗[J].常州大学学报(自然科学版),2024,36(04):82-92.[doi:10.3969/j.issn.2095-0411.2024.04.010]
 HU Hang,XIAO Wen,TAO Yayu,et al.New indocyanine green-loaded reduction responsive polymeric micelles for enhanced cancer photodynamic therapy[J].Journal of Changzhou University(Natural Science Edition),2024,36(04):82-92.[doi:10.3969/j.issn.2095-0411.2024.04.010]
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负载新吲哚菁绿的还原响应性聚合物胶束增强肿瘤光动力治疗()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
第36卷
期数:
2024年04期
页码:
82-92
栏目:
生物医药工程
出版日期:
2024-07-28

文章信息/Info

Title:
New indocyanine green-loaded reduction responsive polymeric micelles for enhanced cancer photodynamic therapy
文章编号:
2095-0411(2024)04-0082-11
作者:
胡航肖文陶亚宇杜坤达袁晓音徐德锋
(常州大学 药学院, 江苏 常州 213164)
Author(s):
HU Hang XIAO Wen TAO Yayu DU Kunda YUAN Xiaoyin XU Defeng
(School of Pharmacy, Changzhou University, Changzhou 213164, China)
关键词:
新吲哚菁绿 光动力治疗 聚乙二醇 胆固醇 胶束 还原响应性
Keywords:
new indocyanine green photodynamic therapy polyethylene glycol cholesterol micelles reduction responsiveness
分类号:
R 94
DOI:
10.3969/j.issn.2095-0411.2024.04.010
文献标志码:
A
摘要:
首先合成了二硫键连接的甲氧基聚乙二醇-胆固醇偶联物mPEG5000-SS-CH和mPEG2000-SS-CH,然后通过溶剂扩散法制备了IR820@mPEG5000-SS-CH和IR820@mPEG2000-SS-CH这两种载新吲哚菁绿(New indocyanine green, IR820)胶束,可以显著提高IR820在生理环境下的稳定性。体外药物释放研究显示两种载IR820胶束均具有还原响应性释放特性,细胞摄取研究表明IR820@mPEG2000-SS-CH比游离IR820和IR820@mPEG5000-SS-CH具有更高的细胞摄取量,体外细胞实验显示mPEG5000-SS-CH和mPEG2000-SS-CH具有良好的生物相容性,IR820@mPEG2000-SS-CH比游离IR820和IR820@mPEG5000-SS-CH具有更强的肿瘤细胞光动力杀伤作用。研究制备的IR820@mPEG2000-SS-CH为提高IR820稳定性和肿瘤光动力治疗作用提供了新的选择。
Abstract:
In this study, disulfide bonded methoxypolyethylene glycol-cholesterol conjugates mPEG5000-SS-CH and mPEG2000-SS-CH were synthesized. The two types of IR820-loaded micelles, IR820@mPEG5000-SS-CH and IR820@mPEG2000-SS-CH, which might significantly improve the stability of IR820 in physiological environment, were prepared by solvent diffusion method. While vitro studies show that both mPEG5000-SS-CH and mPEG2000-SS-CH have reduction-responsive release characteristics and good biocompatibility, IR820@mPEG2000-SS-CH displays enhanced cellular uptake and photodynamic killing effect on tumor cells as compared to free IR820 and IR820@mPEG5000-SS-CH. The study suggests that IR820@mPEG2000-SS-CH could be a new choice with superior stability and cancer photodynamic therapeutic effect to IR820.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期: 2024-02-15。
基金项目: 江苏省高等学校自然科学研究面上资助项目(20KJB350005); 常州市重点研发计划资助项目(CJ20210030)。
作者简介: 胡航(1989—), 男, 安徽蚌埠人, 博士, 助理研究员。 通信联系人: 徐德锋(1968—), E-mail: markxu@cczu.edu.cn
更新日期/Last Update: 1900-01-01