[1]邱 滔,吴增辉,吕新宇.噻唑-4-甲酸的合成[J].常州大学学报(自然科学版),2012,(01):21-23.
　QIU Tao,WU Zeng-hui,LV Xin-yu.Synthesis of Thiazole-4-Carboxylic Acid[J].Journal of Changzhou University(Natural Science Edition),2012,(01):21-23.
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噻唑-4-甲酸的合成()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2012年01期
页码:
21-23
栏目:
出版日期:
2012-01-01

文章信息/Info

Title:
Synthesis of Thiazole-4-Carboxylic Acid
作者:
邱 滔; 吴增辉; 吕新宇
常州大学 设计研究院,江苏 常州 213164
Author(s):
QIU Tao; WU Zeng-hui; LV Xin-yu
Institute of Design and Research, Changzhou University, Changzhou 213164,China
关键词:
噻唑-4-甲酸;  氧化反应;  合成
Keywords:
Thiazole-4-carboxylic acid;  oxidation reaction;  synthetize
分类号:
TQ 463.25
文献标志码:
A
摘要:
以L-半胱氨酸盐酸盐与甲醛为起始原料,经缩合酯化得到噻唑烷-4-甲酸甲酯,再在二氧化锰作用下氧化合成噻唑-4-甲酸甲酯,水解得到噻唑-4-甲酸。氧化反应最佳反应条件为n(噻唑-4-甲酸甲酯):n(MnO2)=1:23、MnO2活化温度为300 ℃、80 ℃反应48 h。氧化反应收率为80.8%。
Abstract:
Methyl thiazolidine-4-carboxylate was synthesized from L-Cysteine hydrochloride and formaldehyde by condensation and esterification. Methylthiazole-4-carboxylate was synthesized by oxidation reaction. Thiazole-4-carboxylic acid was achieved from hydrolysis reaction. The mole ratio of methyl thiazole-4-carboxylate to MnO2 was 1:23, the activation temperature of MnO2 was 300 ℃,reaction for 48 h at 80 ℃. The yield of oxidation reaction was 80.8%.

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备注/Memo

备注/Memo:
作者简介:邱滔(1967-),男,江苏常州人,研究员。
更新日期/Last Update: 2012-01-01