[1]方永勤,张敏敏.2-巯基-3-三氟乙氧基吡啶的合成研究[J].常州大学学报(自然科学版),2013,(02):64-66.[doi:10.3969/j.issn.2095-0411.2013.02.016]
　FANG Yong qin,ZHANG Min min.Synthesis of 3-(2,2,2-Trifluoroethoxy)Pyridine-2-Thiol[J].Journal of Changzhou University(Natural Science Edition),2013,(02):64-66.[doi:10.3969/j.issn.2095-0411.2013.02.016]
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2-巯基-3-三氟乙氧基吡啶的合成研究()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2013年02期
页码:
64-66
栏目:
出版日期:
2013-03-30

文章信息/Info

Title:
Synthesis of 3-(2,2,2-Trifluoroethoxy)Pyridine-2-Thiol
作者:
方永勤; 张敏敏
常州大学 设计研究院,江苏 常州 213164
Author(s):
FANG Yong qin; ZHANG Min min
Institute of Design and Research,Changzhou University,Changzhou 213164,China
关键词:
2-巯基-3-三氟乙氧基吡啶;  2-氯-3-羟基吡啶;  三氟啶磺隆;  醚化;  巯基化
Keywords:
3-(2; 2; 2-trifluoroethoxy)pyridine-2-thiol;  2-chloro-3-hydroxypyridine;  trifloxysulfuron;  etherification;  thiolate
分类号:
TQ 454.2
DOI:
10.3969/j.issn.2095-0411.2013.02.016
文献标志码:
A
摘要:
以三氟乙醇和对甲苯磺酰氯为原料,通过亲核取代,Williamson醚化及巯基化反应制得2-巯基-3-三氟乙氧基吡啶,着重对醚化、巯基化反应的工艺进行优化,3步反应总收率71.4%,产品纯度98.0%(HPLC)。中间体及目标产物经IR、1H NMR确认。
Abstract:
3-(2,2,2-trifluoroethoxy)pyridine-2-thiol was prepared with trifluoroethanol and tosyl chloride through nucleophilic substitution,Williamson etherification and thiolation.The effects of the reaction conditions of etherification and thiolation on the yields were investigated.The total yieldwas 71.4%,and the purity of target product was 98.0%(HPLC).All compounds obtained were identified by IR and 1H NMR.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:方永勤(1966-),女,江苏姜堰人,研究员级高级工程师。
更新日期/Last Update: 2013-03-30