[1]周晓鹰,魏 涛.哮喘疾病中肥大细胞与气道平滑肌细胞的相互作用[J].常州大学学报(自然科学版),2018,30(04):87-92.[doi:10.3969/j.issn.2095-0411.2018.04.014]
　ZHOU Xiaoying,WEI Tao.Interactions Between Mast Cells and Airway Smooth Muscle Cells in Asthma[J].Journal of Changzhou University(Natural Science Edition),2018,30(04):87-92.[doi:10.3969/j.issn.2095-0411.2018.04.014]
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哮喘疾病中肥大细胞与气道平滑肌细胞的相互作用()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
第30卷
期数:
2018年04期
页码:
87-92
栏目:
生物医学工程
出版日期:
2018-07-28

文章信息/Info

Title:
Interactions Between Mast Cells and Airway Smooth Muscle Cells in Asthma
作者:
周晓鹰1; 2; 魏 涛1
1. 常州大学 制药与生命科学学院,江苏 常州 213164; 2. 英国南安普顿大学 医学院,南安普顿 SO16 6YD
Author(s):
ZHOU Xiaoying1; 2;  WEI Tao1
1. School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China; 2. The School of Medicine, University of Southampton, Southampton SO16 6YD, UK
关键词:
哮喘;  肥大细胞;  气道平滑肌细胞
Keywords:
asthma;  mast cells;  airway smooth muscle cells
分类号:
R 562.1
DOI:
10.3969/j.issn.2095-0411.2018.04.014
文献标志码:
A
摘要:
哮喘的特征是气道高反应性、炎症和气道重塑。肥大细胞和气道平滑肌细胞在哮喘发病过程中起到重要的作用。研究表明促成哮喘发病的这两种细胞类型之间存在串扰。近年来,肥大细胞和气道平滑肌细胞的相互作用以及这种相互作用和哮喘疾病发病的关系的研究有了进一步的发展。深入研究两者的生物学功能、在哮喘中的作用机制以及两者间的相互关系,可为寻找治疗哮喘或过敏性哮喘药物的新靶标提供基础理论依据,为哮喘和过敏性哮喘等多种疾病的前期诊断和治疗提供更广阔的思路。
Abstract:
Asthma is characterized by airway hyperresponsiveness, inflammation and airway remodeling. Mast cells and airway smooth muscle cells both play important roles in the pathogenesis of asthma. Studies have shown that there is crosstalk between these two cell types that contribute to asthma. In recent years, the interaction between mast cells and airway smooth muscle cells and the associations with the progress of asthma have been further studied in-depth. It is very important to understand the biological function of both cells and the mechanism of interactions between both types of cells in asthma for new drugs development. Also, the studies on the interaction of mast cells and airway smooth muscle cells will provide a new insight for the diagnosis and treatment of relevant airway diseases.

参考文献/References:


[1] BICE J B,LEECHAWENGWONGS E,MONTANARO A. Biologic targeted therapy in allergic asthma [J]. Annals of Allergy, Asthma & Immunology,2014,112(2):108-115.
[2]VALKONEN M,WOUTERS I M,TAUBEL M,et al. Bacterial exposures and associations with atopy and asthma in children [J]. Plos One,2015,10(6):e0131594.
[3]REBER L L,SIBILANO R,MUKAI K,et al. Potential effector and immunoregulatory functions of mast cells in mucosal immunity [J]. Mucosal Immunology,2015,8(3):444-463.
[4]HINKS T,ZHOU X,STAPLES K,et al. Multidimensional endotypes of asthma:topological data analysis of cross-sectional clinical, pathological, and immunological data [J]. Lancet,2015,385(Suppl 1):S42.
[5]HINKS T S,ZHOU X,STAPLES K J,et al. Innate and adaptive T cells in asthmatic patients: relationship to severity and disease mechanisms [J]. Journal of Allergy & Clinical Immunology,2015,136(2):323-333.
[6]ZHOU X,COX C,RAJENTHIRAR S,et al. Mast cell chymase can disrupt the human bronchial epithelium and stimulate the loss of adhesion molecules [J]. Journal of Allergy & Clinical Immunology,2008,121(2):S110.
[7]DAHLIN J S,HALLGREN J. Mast cell progenitors:origin,development and migration to tissues [J]. Molecular Immunology,2015,63(1):9-17.
[8]KRITAS S K,SAGGINI A,CERULLI G,et al. Asthma and mast cell biology[J]. European Journal of Inflammation,2014,12(2):261-265.
[9]GALLI S J,TSAI M. IgE and mast cells in allergic disease [J]. Nature Medicine,2012,18(5):693-704.
[10]LUNDEQUIST A,PEJLER G. Biological implications of preformed mast cell mediators[J]. Cellular & Molecular Life Sciences Cmls,2010,68(6):965-975.
[11]HOLGATE S T,SALVI S S. Mast cell tryptase as a proinflamatory mediator in late-phase asthmatic response [J]. Current Allergy and Asthma Reports,2002,2(2):105-106.
[12]NOBLE P B,PASCOE C D,LAN B,et al. Airway smooth muscle in asthma:linking contraction and mechanotransduction to disease pathogenesis and remodeling [J]. Pulmonary Pharmacology & Therapeutics,2014,29(2):96-107.
[13]KIMURA K,EGUCHI S. Angiotensin II type-1 receptor regulates RhoA and Rho-kinase/ROCK activation via multiple mechanisms [J]. American Journal of Physiology Cell Physiology,2009,297(5):1059-1061.
[14]MIZUNO Y,ISOTANI E,HUANG J,et al. Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo [J]. American Journal of Physiology Cell Physiology,2008,295(2):358-364.
[15]TLIBA O,JR P R. Noncontractile functions of airway smooth muscle cells in asthma [J]. Middletons Allergy,2014,71(71):315-326.
[16]TLIBA O,PANETTIERI R A. Regulation of inflammation by airway smooth muscle [J]. Current Allergy & Asthma Reports,2008,8(3):262-268.
[17]SCHAAFSMAAB D,ZAAGSMA J,HALAYKO A J,et al. Rho kinase inhibitors:a novel therapeutical intervention in asthma? [J]. European Journal of Pharmacology,2008,585(2/3):398-406.
[18]HARADA T,YAMASAKI A,CHIKUMI H,et al. γ-Tocotrienol reduces human airway smooth muscle cell proliferation and migration [J]. Pulmonary Pharmacology & Therapeutics,2015,32:45-52.
[19]HU R,PAN W,FEDULOV A V,et al. MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway [J]. The FASEB Journal,2014,28(5):2347-2357.
[20]JAMES A,GYLLFORS P,HENRIKSSON E,et al. Corticosteroid treatment selectively decreases mast cells in the smooth muscle and epithelium of asthmatic bronchi [J]. Allergy,2012,67(7):958-961.
[21]CARTER R J,BRADDING P. The role of mast cells in the structural alterations of the airways as a potential mechanism in the pathogenesis of severe asthma [J]. Current pharmaceutical design,2011,17(7):685-698.
[22]MUNAKATA M. Airway remodeling and airway smooth muscle in asthma [J]. Allergology International Official Journal of the Japanese Society of Allergology,2006,55(3):235-243.
[23]BRADDING P. Mast cell regulation of airway smooth muscle function in asthma [J]. European Respiratory Journal,2007,29(5):827-830.
[24]KIM Y S,KO H M,KANG N I,et al. Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-alpha in a murine model of asthma [J]. European Journal of Immunology,2010,37(4):1107-1115.
[25]AMRANI Y. Modulation of airway smooth muscle contractile function by TNFα and IL-13 and airway hyperresponsiveness in asthma [M]. Switzerland:Springer International Publishing,2014:423-439.
[26]BUSSE W W. The relationship of airway hyperresponsiveness and airway inflammation: airway hyperresponsiveness in asthma:its measurement and clinical significance [J]. Chest,2010,138(2):4S-10S.
[27]LARSSON J,PERRY C P,ANDERSON S D,et al. The occurrence of refractoriness and mast cell mediator release following mannitol-induced bronchoconstriction [J]. Journal of Applied Physiology,2011,110(4):1029-1035.
[28]RUDICH N,DEKEL O,SAGIEISENBERG R. Down-regulation of the A3 adenosine receptor in human mast cells upregulates mediators of angiogenesis and remodeling [J]. Molecular Immunology,2015,65(1):25-33.
[29]ALKHOURI H,HOLLINS F,MOIR L M,et al. Human lung mast cells modulate the functions of airway smooth muscle cells in asthma [J]. Allergy,2011,66(9):1231-1241.
[30]WOODMAN L. Cellular interactions of airway smooth muscle and human lung mast cells [D]. Leicester:University of Leicester,2008.
[31]MANNING B M,MEYER A F,GRUBA S M,et al. Single-cell analysis of mast cell degranulation induced by airway smooth muscle-secreted chemokines [J]. Biochimica Et Biophysica Acta,2015,1850(9):1862-1868.
[32]XIA Y X C. Human airway smooth muscle cell and mast cell communication in asthma and its regulation by antibody-Fc receptors [D]. Melbourne:The University of Melbourne,2010.
[33]谢柏梅,戚好文. 气道平滑肌肥大细胞浸润与哮喘的关系[J]. 国际呼吸杂志,2007,27(1):56-59.

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备注/Memo

备注/Memo:
基金项目:常州大学高层次人才引进启动基金(ZMF14020066); 常州科技局国际交流研究基金(CZ20150014); 英国British Medical Research Council, UK(G0500729)。
作者简介:周晓鹰(1957—),女,博士,常州大学外籍特聘教授,英国南安普顿大学客座教授。E-mail:xiaoyingzhou@cczu.edu.cn
更新日期/Last Update: 2018-07-30