[1]周新莹,张辛燕.山竹醇对癌症的化学预防作用[J].常州大学学报(自然科学版),2014,(04):30-36.[doi:10.3969/j.issn.2095-0411.2014.04.007]
 ZHOU Xin-ying,ZHANG Xin-yan.Chemopreventive Effects of Garcinol against Cancers[J].Journal of Changzhou University(Natural Science Edition),2014,(04):30-36.[doi:10.3969/j.issn.2095-0411.2014.04.007]
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山竹醇对癌症的化学预防作用()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2014年04期
页码:
30-36
栏目:
生物医学工程
出版日期:
2014-08-31

文章信息/Info

Title:
Chemopreventive Effects of Garcinol against Cancers
作者:
周新莹张辛燕
首都医科大学附属北京口腔医院 口腔医学研究所,北京 100050
Author(s):
ZHOU Xin-yingZHANG Xin-yan
Beijing Institute of Dental Research,Beijing Stomatological Hospital,Capital Medical University,Beijing 100050,China
关键词:
癌症 化学预防 山竹醇
Keywords:
cancers chemopreventive effect garcinol
分类号:
R 739.8
DOI:
10.3969/j.issn.2095-0411.2014.04.007
文献标志码:
A
摘要:
山竹醇是来源于印度藤黄和其他相关种类植物的多聚异戊二烯基苯甲酮。尽管这种水果在热带地区已经使用了上百年,但它的生物活性,尤其是它的抗癌潜能是在近年来的科学研究中才发现的。一些研究显示,山竹醇对多种癌具有抗癌潜能,包括乳腺癌、结肠癌、胰腺癌、口腔癌、肝细胞癌和白血病等。山竹醇的抗癌特性通过抗氧化、抗炎、抗增殖及诱导细胞凋亡和抑制组蛋白乙酰转移酶所表现出来。目前就山竹醇的抗癌特性而言,它是一种有前途的抗癌剂,但是后期还需要相关的动物实验研究和临床试验,更充分地了解并确认其化学预防和/或治疗潜力。
Abstract:
Garcinol is a polyisoprenylated benzophenone derived from Garcinia indica and other related species.Although the fruit has been consumed traditionally over centuries in tropical regions,its biological activities,especiaally its anticancer potential,is a result of recent scientific investigations.Some studies have shown the potential of this compound against several kinds of cancers including breast,colon,pancreatic,oral,hepatocellular and leukemia.The anticarcinogenic properties of garcinol appear to be mediated via its antioxidative activity,antiinflammatory activity,antiproliferation and inducing apoptosis as well as inhibiting histone acetyltransferases.At the present time,garcinol is a promising anticanceragent in terms of its anticancer properties,subsequent investigations in relevant animal models and clinical trials are warranted in order to fully appreciateand confirm its chemopreventive and/or therapeutic potential.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金面上项目(81272982); 北京市卫生系统高层次卫生人才项目(20113073)。 作者简介:周新莹(1988-),女,贵州贵阳人,硕士生。通讯联系人:张辛燕(1970-),Email:xinyanzhangzh@126.com
更新日期/Last Update: 2014-12-20