[1]陈再新,刘 雯,张明光,等.新型2型糖尿病治疗药物SGLT-2抑制剂的临床研究进展[J].常州大学学报(自然科学版),2014,(04):37-44.[doi:10.3969/j.issn.2095-0411.2014.04.008 ]
 CHEN Zai-xin,LIU Wen,ZHANG Ming-guang,et al.Clinical Research Progress of SGLT-2 Inhibitors,a Novel Treatment of Type 2 Diabetes[J].Journal of Changzhou University(Natural Science Edition),2014,(04):37-44.[doi:10.3969/j.issn.2095-0411.2014.04.008 ]
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新型2型糖尿病治疗药物SGLT-2抑制剂的临床研究进展()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2014年04期
页码:
37-44
栏目:
生物医学工程
出版日期:
2014-08-31

文章信息/Info

Title:
Clinical Research Progress of SGLT-2 Inhibitors,a Novel Treatment of Type 2 Diabetes
作者:
陈再新刘 雯张明光蒋晓勤吉小龙
亚邦医药研究院,江苏 常州 213145
Author(s):
CHEN Zai-xinLIU WenZHANG Ming-guangJIANG Xiao-qingJI Xiao-long
Yabang Medical Research Institute,Changzhou 213145,China
关键词:
钠-葡萄糖协同转运蛋白2 SGLT-2抑制剂 2型糖尿病 降血糖药物
Keywords:
sodium-glucose co-transporter 2 SGLT-2 inhibitors type2 diabetes antihyperglycemic agents
分类号:
R 97
DOI:
10.3969/j.issn.2095-0411.2014.04.008
文献标志码:
A
摘要:
钠-葡萄糖协同转运蛋白2(SGLT-2)抑制剂是一类全新作用机制的降糖药物。它通过抑制葡萄糖在肾脏的重吸收,以增加尿糖的排泄,调节体内的血糖浓度,从而达到治疗2型糖尿病的目的。由于其独特的作用机制,SGLT-2抑制剂已经成为近年来降糖药物研究中最具发展潜力的新药。针对已上市和已进入临床研究的SGLT-2抑制剂中的重点化合物,综述其最新的临床研究进展。
Abstract:
Sodiumglucose co-transporter 2(SGLT-2)inhibitors area class of antihyperglycemic agents with new mechanism of action.They can be used for treatment of type 2 diabetes by inhibiting the renal glucose reabsorption,thereby increasing the urinary glucose excretion,regulating the blood glucose levels.Because of the unique mechanism of action,SGLT-2 inhibitors have become very promising for the development of new antihyperglycemic drugs.This paper reviewed the latest clinical research progress of the important SGLT-2 inhibitors,which are already marketed or in clinical trials.

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备注/Memo

备注/Memo:
作者简介:陈再新(1970-),男,安徽池州人,博士,研究员级高工,主要从事新药研究和开发工作。Email: zaixin_chen@163.com
更新日期/Last Update: 2014-12-20