[1]王昕宇,徐崇福,陈 颖,等.药物中间体4-氯苯基苄基酮的合成[J].常州大学学报(自然科学版),2012,(02):31-34.
　WANG Xin-yu,XU Chong-fu,CHEN Ying,et al.Study of the Synthesis of Pharmaceutical Intermediate 4-Chlorophenylbenzylketone[J].Journal of Changzhou University(Natural Science Edition),2012,(02):31-34.
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药物中间体4-氯苯基苄基酮的合成()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2012年02期
页码:
31-34
栏目:
出版日期:
2012-03-30

文章信息/Info

Title:
Study of the Synthesis of Pharmaceutical Intermediate 4-Chlorophenylbenzylketone
作者:
王昕宇; 徐崇福;  陈 颖;  张杜娟; 李艺林
常州大学 石油化工学院,江苏 常州 213164
Author(s):
WANG Xin-yu; XU Chong-fu; CHEN Ying; ZHANG Du-juan; LI Yi-lin
School of Petrochemical Engineering,Changzhou University,Changzhou 213164,China
关键词:
4-氯苯基苄基醇;  4-氯苯基苄基酮;  格氏反应;  氧化
Keywords:
4-chlorophenylbenzylmethanol;  4-chlorophenylbenzylketone;  Grignard reaction;  oxidation
分类号:
O 625.42
文献标志码:
A
摘要:
以氯化苄和对氯苯甲醛为原料,通过格氏法合成4-氯苯基苄基醇,进一步经硅胶负载氯铬酸吡啶(PCC)氧化为成4-氯苯基苄基酮。总产率为75.0%。探讨多种因素对收率的影响,获得控制反应过程的最佳参数。通过IR、1H NMR、13C NMR对产物的结构进行了分析表征。
Abstract:
4-chlorophenylbenzylmethanol was synthesized via Grignardmethod using benzyl chloride and p-chlorobenzaldehyde as starting materials, subsequent oxidation by silica gel loaded pyridinium chlorodichromate afforded 4-chlorophenylbenzylketone with 75% overall yield. Various factors on the yield ofproducts were explored, and the optimal parameters for controlling reaction processes were obtained. The molecular structures of the products were characterized using infrared, 1H and 13C nuclear magnetic resonance spectroscopy.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:王昕宇(1985-),男,江苏淮安人,硕士生
更新日期/Last Update: 2012-03-30