[1]张　静,徐　鸽,孙　琦.新药“宁静液” 的药效、毒理实验研究[J].常州大学学报(自然科学版),2001,(01):21-23.
　ZHANG Jing,XU Ge,SUN Qi.Study on Pharmacology and Toxicology of the New Drug “Ningjingye”[J].Journal of Changzhou University(Natural Science Edition),2001,(01):21-23.
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新药“宁静液” 的药效、毒理实验研究()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2001年01期
页码:
21-23
栏目:
出版日期:
2001-03-25

文章信息/Info

Title:
Study on Pharmacology and Toxicology of the New Drug “Ningjingye”
作者:
张　静1 ;  徐　鸽1 ;  孙　琦2
1.江苏石油化工学院化学工程系, 江苏 常州 213016 ;2.威康特塑料公司, 江苏 常州 213015
Author(s):
ZHANG Jing 1 ;  XU Ge1 ;  SUN Qi2
1 .Department of Chemical Engineering , Jiangsu Insti tute of Petrochemical Technology , Changzhou 213016 , China ;2 .Chang zhou Viscount Plastics Co .Ltd ., Changzhou 213015 , China
关键词:
宁静液; 急性软组织挫伤; 毒理; 药效
Keywords:
Ningjingye ; acute injuries of soft t issue ; toxicology reaction ; efficacy of a drug
分类号:
R 965.2
文献标志码:
A
摘要:
研究从阔叶树木中提取、分离、配制的木质素类中药宁静液, 对急性软组织挫伤及皮肤破损方面进行了药效试验, 为临 床安全用药提供科学依据。对小鼠进行口服, 对豚鼠进行完整和破损皮肤药物接触后可能产生的毒性反应, 过敏反应及刺激反 应。宁静液对小鼠口服给药的最大耐受量为80 m L/ kg 。皮肤受药后在激发24 小时、48 小时、72 小时皮肤未见一例出红斑, 判 定宁静液无过敏反应, 经皮肤刺激反应评分标准判定平均分值为0.16 , 可判定宁静液为无刺激性。
Abstract:
The ef ficacy of Ningjingye on acute injures of sof t tissue is studied in order to provide the scientific basis for clinic safety .Ningjingye is a Chinese medicine abstracted , separated and compounded f rom broadleaf trees .In studying the to xicity reaction , the medicine was tried on mice .To observe allergy and stimulation reactions , the medicine was applied to the skin and bruises of guinea pigs .The maximum oral dose for mice is 80 mL/kg .Af ter 24 h , 48 h , 72 h wi th Ningjingye , the erythema was not found in all , that is , there w as no allergy reaction wi th Ningjingye .The average value is 0.16 by evaluation standard of stimulat ion reaction , and it shows no stimulation f rom Ningjingye .

参考文献/References:

[1] 村上浩纪, 工藤正邦.精制リグニンスルホン酸から成ゐ抗肿 疡性物质[P] .日本特许公报:昭53 -6411 , 1978 -01 - 20 .
[2] Dolnikov , Yurij Ya.Pharmaceuticals for Treatment of Gast roenteri tis in Small Animals [P] .Russ :RU 2096033 , 1997 -11 - 20.
[3] Shen Xin , Weaver , Connie M , et al.Lignin Ef fect on Calcium Absorption in Rat s [J] .J Food Sci , 1998 , 63 (1):165 -167.

备注/Memo

备注/Memo:
基金项目:常州市科学技术委员会基金资助([ 2000] 81) 作者简介:张静(1951 -), 女, 上海人, 本科, 主要从事植物化学方面的研究。
更新日期/Last Update: 2001-03-25