[1]何明阳,陈　群.邻氯苄醇的制备[J].常州大学学报(自然科学版),2001,(04):27-29.
　HE Ming -y ang,CHEN Qun.Synthesis of O-Chlorobenzenemethanol[J].Journal of Changzhou University(Natural Science Edition),2001,(04):27-29.
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邻氯苄醇的制备()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2001年04期
页码:
27-29
栏目:
出版日期:
2001-12-25

文章信息/Info

Title:
Synthesis of O-Chlorobenzenemethanol
作者:
何明阳;  陈　群
江苏石油化工学院江苏省精细化工重点实验室, 江苏 常州 213016
Author(s):
HE Ming -y ang ;  CHEN Qun
Key Laboratory of Fine Chemical Engineering , Jiangsu Institute of Pet rochemical Technology , Changzhou 213016 , China
关键词:
邻氯苄醇; 邻氯苯甲醛; 坎尼扎罗反应
Keywords:
o -chlorobenzenemethanol ; o -chlorobenzaldehy de ; Cannizzuro reaction
分类号:
T Q 243.4
文献标志码:
A
摘要:
探讨了以邻氯苯甲醛与甲醛为主要原料, 通过交叉的Conni zzaro 反应制备邻氯苄醇的工艺条件。主要考察了反应物的配 比对邻氯苄醇收率的影响, 当邻氯苯甲醛、甲醛和氢氧化钠物质的量比为1.0∶1.3∶3.5 , 氢氧化钠的质量分数为50 %, 以甲醇 为溶剂时, 邻氯苄醇的收率达到91.93 %。
Abstract:
O -Chlorobenzenemethanol was prepared by way of cross Cannizzaro reaction , using o -chlorobenzaldehyde and formaldehyde as the main material .When the molar ratio of o-chlo robenzaldehy de 、formaldehyde and sodium hydroxide w as 1.0∶1.3∶3.5 , the concentration of sodium hydroxide w as 50 %, and methanol as solvent , the yield of o -chlorobebzenemethanol w as 91.93 %.

参考文献/References:

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[3] Hill Jam es .Pharmaceu tical Com positions , Preparat ion and Use of Angiotensin II Recept or Ant agoni sts for The T reatment of Atherama [P] .WO 9210184 , 1992 -06 -25 .
[4] Bianco A , Passacanti lli P , Righi G .Improved Procedure for The Production of Esters to Alcohols by Sodium Borohydride [J] . Synth Commun , 1988 , 18 (15):1 765 -1 771 .
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备注/Memo

备注/Memo:
作者简介:何明阳(1962 -), 男, 江苏泰兴人, 副教授, 主要从事有机合成和精细化学品开发方面的研究。
更新日期/Last Update: 2001-12-25