[1]郭登峰,潘剑波,凌达仁,等.新型手性毛细管柱的研制及对手性物质的分离[J].常州大学学报(自然科学版),2004,(03):31-33.
　GUO Deng - feng,PAN J ian - bo,L IN Da - ren,et al.Preparation of New Chiral Capillary Column and Study of its Chromatographic Performance[J].Journal of Changzhou University(Natural Science Edition),2004,(03):31-33.
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新型手性毛细管柱的研制及对手性物质的分离()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2004年03期
页码:
31-33
栏目:
出版日期:
2004-09-25

文章信息/Info

Title:
Preparation of New Chiral Capillary Column and Study of its Chromatographic Performance
作者:
郭登峰;  潘剑波;  凌达仁;  陈　洁
江苏工业学院化学工程系, 江苏 常州 213016
Author(s):
GUO Deng - feng ;  PAN J ian - bo ;  L IN Da - ren ;  CHENGJ i
Department of Chemical Engineering , J iangsu Polytechnic University , Changzhou 213016 , China
关键词:
环糊精衍生物;  气相色谱;  拆分;  对映体
Keywords:
β- cyclodext rin derivatives ;  barium sulphate midified column ;  enantiomer seperation ;  gas chro2 matography
分类号:
O 658.1 ; TS 236.9
文献标志码:
A
摘要:
以β- 环糊精衍生物为固定相, 色谱法分离对映体是现代科学研究的重点之一。研究了合成两种新的β- 环糊精衍生物色 谱固定相, 2 , 3 , 6 - 三- O - 三庚基-β- CD ( THPCD) 和2 , 6 - O - 二庚基- 3 - O - 乙酰基-β- CD (DHACD) , 以OV - 1701 为稀释剂, 采用动态法, 制备了新型毛细管色谱柱, 从柱的分离选择性、惰性、柱效、稀释剂的配比等方面作了较为系统 的研究, 并初步探讨了β- 环糊精衍生物固定相可能的手性拆分机理。
Abstract:
Two newβ- cyclodext rin derivatives , THPCD ( Ⅰ) and DHACD ( Ⅱ) , were synthesized. Being dissolved in OV - 1701 , the cyclodext rin derivatives were used as gas chromaotographic ( GC) stationary phase to prepare new chiral capillary columns , the wall of which had been modified by BaSO4 prior to coating. Capil2 lary columns were coated by superdynamic method. Systematic examinations , such as separation ability. Col2 umn efficiency , stability had been discussed. Enantiomeric separation was performed on chiral capillary column coated with Ⅰand Ⅱ. The result s showed that Ⅱ has higher enantioselectivity than Ⅰ for chiral alcohols , amines.

参考文献/References:

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[2] Armstrong D W, Li W Y. Capillary Gas Chromatography Separa2 tion of Enantionmers with Stable Dipentyl - α- , β- andγ- Cy2 clodextrin - Derivatized Stationary Phases [J] . Anal Chimacta , 1991 , 234 : 365 - 3801
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[5] 寇登民, 云稀勤, 王宏, 等1 硫酸钡微晶改性毛细管柱的制备 极其分离性能的研究[J] 1 分析化学, 1993 , 21 (5) : 504 - 5081
[6] 傅若农, 戴荣继, 周伟1 毛细管气相色谱在工业分析中的应用 [J] 1 北京理工大学学报, 1996 , 16 (2) : 176 - 1801
[7] 阎建辉, 唐阔文1 改性环糊精手性毛细管柱的研制及拆分机理 [J] 1 精细化工中间体, 2001 , 31 (2) : 13 - 151
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备注/Memo

备注/Memo:
基金项目: 江苏工业学院科技基金资助 作者简介: 郭登峰(1964 - ) , 男, 江苏南通人, 高级实验师, 主要从事色谱及工业分析方面的教学和研究。
更新日期/Last Update: 2004-09-25