[1]方永勤,郭丽婷.4,6-二氯-2-甲硫基嘧啶的合成[J].常州大学学报(自然科学版),2011,(01):15-18.
　FANG Yong-qin,GUO Li-ting.Research on the Synthesis of 4,6-Dichloro-2-Methylthiopyrimidine[J].Journal of Changzhou University(Natural Science Edition),2011,(01):15-18.
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4,6-二氯-2-甲硫基嘧啶的合成()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2011年01期
页码:
15-18
栏目:
出版日期:
2011-01-01

文章信息/Info

Title:
Research on the Synthesis of 4,6-Dichloro-2-Methylthiopyrimidine
作者:
方永勤; 郭丽婷
常州大学 设计研究院,江苏 常州 213164
Author(s):
FANG Yong-qin;  GUO Li-ting
Institute of Design and Research, Changzhou University,Changzhou 213164,China
关键词:
4; 6-二氯-2-甲硫基嘧啶;  氯化;  缚酸剂;  甲基化
Keywords:
4; 6-dichloro-2-methylthiopyrimidine;  chloration;  acid-catcher;  methylation
分类号:
TQ 254.1
文献标志码:
A
摘要:
以硫脲,丙二酸二乙酯为起始原料,经环合得到2-硫代巴比妥酸钠盐,收率96.7%; 硫甲基化得到4,6-二羟基-2-甲硫基嘧啶,收率86.9%; 再在三氯氧磷,三乙胺作用下氯化合成了高纯度的4,6-二氯-2-甲硫基嘧啶,收率91.5%。反应总收率76.9%,产品含量≥99.0%。中间体及目标产品结构经1H NMR,IR确认。
Abstract:
Sodium 2-thiobarbiturate was synthesized from the reaction of thiourea and diethyl malonate, with 96.7% yield. 4,6-Dihydroxy-2-methylthiopyrimidine was prepared by methylation of sodium 2-thiobarbiturate, with 86.9% yield. 4,6-Dichloro-2-methylthiopyrimidine was achieved by chloration, with 91.5% yield. The total yield was 76.9%.The content of the product was more than99.0%.The structures of the intermediates and target product were identified by IR and 1H NMR.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:方永勤(1966-),女,江苏姜堰人,研究员级高级工程师
更新日期/Last Update: 2011-01-01