[1]冷一欣,张 兆,黄春香,等.蔗糖-6-乙酯制备三氯蔗糖的工艺[J].常州大学学报(自然科学版),2011,(02):20-23.
　LENG Yi-xin,ZHANG Zhao,HUANG Chun-xiang,et al.Study of the Synthesis of Sucralose by Sucrose-6-Acetate[J].Journal of Changzhou University(Natural Science Edition),2011,(02):20-23.
点击复制

蔗糖-6-乙酯制备三氯蔗糖的工艺()
分享到：

常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2011年02期
页码:
20-23
栏目:
出版日期:
2011-03-30

文章信息/Info

Title:
Study of the Synthesis of Sucralose by Sucrose-6-Acetate
作者:
冷一欣; 张 兆; 黄春香; 刘晓成; 王兴康
常州大学 石油化工学院,江苏 常州 213164
Author(s):
LENG Yi-xin; ZHANG Zhao; HUANG Chun-xiang; LIU Xiao-cheng; WANG Xin-kang
School of Petrochemical Engineering, Changzhou University, Changzhou 213164,China
关键词:
蔗糖-6-乙酯;  Vilsmeier试剂;  三氯蔗糖-6-乙酯;  三氯蔗糖
Keywords:
sucrose-6-acetate;  Vilsmeier reagent;  sucralose-6-acetate;  sucralose
分类号:
TQ 207
文献标志码:
A
摘要:
以蔗糖-6-乙酯为原料,Vilsmeier试剂为氯化剂,对蔗糖-6-乙酯进行选择性氯化,制得三氯蔗糖-6-乙酯,在碱性条件下脱除乙酰基,制得三氯蔗糖。考察了反应温度、反应时间对氯化反应的影响,碱的种类、反应温度和pH值对脱乙酰基反应的影响。研究结果表明:在110 ℃条件下,蔗糖-6-乙酯与Vilsmeier试剂反应2 h,三氯蔗糖-6-乙酯收率较好,为51.9%; 在-10 ℃条件下,用KOH溶液调节pH=9,反应4 h得到三氯蔗糖,收率为80.2%。产物结构经IR、1H NMR、13C NMR表征分析。
Abstract:
Sucralose-6-acetate was synthesized by chlorination withVilsmeier reagent, using sucrose-6-acetate as the raw material. Sucralose was obtained from sucralose-6-acetate under the condition of alkaline. The effects of reaction temperature and reaction time on chlorination were investigated. The effects of the types of deacetylation agent, reaction temperature and pH on deacetylation were investigated. The results showed that the yield of sucralose-6-acetate was 51.9% at the reaction temperature 110 ℃ and reaction time 2 h. The results showed that the yield of sucralose was 80.2% at the reaction temperature -10 ℃ and adjusted to pH=9 with KOH. Sucralose was characterized by IR, 1H NMR and 13C NMR.

参考文献/References:

[1]李晔,晏日安,李晓光,等.三氯蔗糖的基团迁移法合成研究[J].食品科学,2004,25(1):50-52.
[2]田铁牛,田玉珍.甜味剂三氯蔗糖的合成技术的研究进展[J].河北化工,2006,29(5):3-6.
[3]陆正清.蔗糖-6-乙酸酯氯化工艺的研究[J].食品科技,2007(3):158-161.
[4]麦克杰纳.蔗糖素[J].中国食品用化学品,1997(6):30-34.
[5]吕绍杰.日本批准使用三氯蔗糖[J].中国食品添加剂,2001(2):49-52.
[6]康维民.三氯蔗糖的特性及其在食品加工中的应用[J].冷饮与速冻食品工业,2001,7(4):11-13.
[7]韦异,粟晖,张英,等.蔗糖-6-乙酸酯的合成方法研究[J].化学世界,2002(10):551-555.
[8]Navia, Juan L. Process for Synthesizing Sucrose Derivatives by Regioselective Reaction:US,4950746[P].1990-06-24.
[9]康文通,杨建民,陈琦,等.新型甜味剂三氯蔗糖的研究[J].中国调味品,2007,32(1):58-61.
[10]Jason D Clark, Fort Collins, Richard R, et al. Method for the Synthesis ofSucrose-6-Acetates:US,6939962[P].2005-09-06.

备注/Memo

备注/Memo:
作者简介:冷一欣(1961-),女,江苏丹阳人,博士,教授,研究方向为绿色化学品及药物中间体的合成。
更新日期/Last Update: 2011-03-30