[1]张治国,孙亿民,江晨,等.人体气道支架的发展与最新研究进展[J].常州大学学报(自然科学版),2017,(01):62-67.[doi:doi:10.3969/j.issn.2095-0411.2017.01.011]
　ZHANG Zhiguo,SUN Yimin,JIANG Chen,et al.The Development of Human Airway Stent and Its Recent Advances[J].Journal of Changzhou University(Natural Science Edition),2017,(01):62-67.[doi:doi:10.3969/j.issn.2095-0411.2017.01.011]
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人体气道支架的发展与最新研究进展()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2017年01期
页码:
62-67
栏目:
生物医学工程
出版日期:
2017-01-28

文章信息/Info

Title:
The Development of Human Airway Stent and Its Recent Advances
作者:
张治国1; 孙亿民1; 2; 江晨1; 2; 李振潇1; 2; 张翼飞1; 3; 邓林红1
1. 常州大学 生物医学工程与健康科学研究院,江苏 常州 213164; 2. 常州大学 机械工程学院,江苏 常州 213164; 3. 常州大学 数理学院,江苏 常州 213164
Author(s):
ZHANG Zhiguo1;  SUN Yimin1; 2;  JIANG Chen1; 2;  LI Zhenxiao1; 2;  ZHANG Yifei1; 3;  DENG Linhong1
1. Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, 213164, China; 2. School of Mechanical Engineering, Changzhou University, Changzhou, 213164, China; 3. School of Mathematics & Physics, Changzhou University, Changzhou, 213164, China
关键词:
气道支架;  Dumon硅酮支架;  镍钛记忆合金气道支架;  药物洗脱气道支架;  生物可降解支架;  3D打印个性化气道支架
Keywords:
airway stent;  Dumon silicone airway stent;  nickel titanium shape memory alloy airway stent;  drug-eluting airway stent;  biodegradable airway stent;  patient-specific airway stent based on the 3D printing
分类号:
TQ 31
DOI:
doi:10.3969/j.issn.2095-0411.2017.01.011
文献标志码:
A
摘要:
由于各种原因所导致的气道狭窄往往需要进行支架植入术以实现气道的快速扩张,缓解患者的呼吸困难。人体气道支架的灵感来源于心血管支架的临床应用,且自1965年Montgomery发明了T型管状硅酮橡胶支架用于气道狭窄的治疗之后,气道支架便得到不断地推陈出新。目前临床上使用的气道支架主要有Dumon硅酮支架和镍钛记忆合金支架。虽然气道支架的植入可以迅速地改善患者的呼吸状况,但支架植入后仍可能会导致一些较为棘手的并发症,例如支架移位、肉芽组织的过度增生以及支架附近组织的感染等。近年来,有关药物洗脱气道支架、生物可降解气道支架的基础研究,为气道支架未来的发展带来了新的曙光,同时,基于生物3D打印技术制备的个性化气道支架可以使得支架与气道实现完美的贴合,既可以降低支架发生移位的风险,又可以实现对肉芽组织过度增生的抑制,必将成为今后气道支架的重要发展趋势之一。
Abstract:
The implantation of airway stent can dilate the airway stenosis quickly and give patients relief from the breathing difficulty. Airway stent takes inspiration from the clinical use of vascular stent and it has been innovated continuously since 1965, when the T-shape silicone airway stent was invented by Montgomery for the treatment of airway stenosis. Currently, Dumon silicone airway stents and nickel titanium shape memory alloy airway stents are widely used in clinics. However, there are still some complications, such as the migration of stent, the excessive growth of granulation tissue and the infections nearby the stent. In recent years, the investigations on the drug-eluting airway stent and the biodegradable airway stent shed new light on the airway stent. Moreover, the patient-specific airway stent based on the 3D printing technology will be one of the important trends for the reason of perfect fit, the low risk of migration and the inhibition of the granulation tissue excessive growth.

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备注/Memo

备注/Memo:
收稿日期:2016-04-27。
基金项目:国家自然科学基金资助项目(11472062,11532003); 江苏省自然科学基金资助项目(13KJB180001)。
作者简介:张治国(1978—),男,山西阳泉人,博士,副研究员,主要从事人体呼吸系统及心血管系统疾病中的力学问题研究。通讯联系人:邓林红(1960—),E-mail:dlh@cczu.edu.cn
更新日期/Last Update: 2017-02-10