[1]周晓鹰,储奕.肥大细胞和类风湿关节炎[J].常州大学学报(自然科学版),2016,(06):28-31.[doi:10.3969/j.issn.2095-0411.2016.06.006]
　ZHOU Xiaoying,CHU Yi.Mast Cells and Rheumatoid Arthritis[J].Journal of Changzhou University(Natural Science Edition),2016,(06):28-31.[doi:10.3969/j.issn.2095-0411.2016.06.006]
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肥大细胞和类风湿关节炎()
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常州大学学报(自然科学版)[ISSN:2095-0411/CN:32-1822/N]

卷:
期数:
2016年06期
页码:
28-31
栏目:
生物医学工程
出版日期:
2016-11-30

文章信息/Info

Title:
Mast Cells and Rheumatoid Arthritis
作者:
周晓鹰; 储奕
1. 常州大学 制药与生命科学学院, 江苏 常州 213164; 2. 英国南安普顿大学 医学院, 南安普顿 SO16 6YD
Author(s):
ZHOU Xiaoying1; 2;  CHU Yi1
1. School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164,China; 2. The School of Medicine,University of Southampton, Southampton SO16 6YD, UK
关键词:
类风湿关节炎;  肥大细胞;  自身免疫疾病
Keywords:
rheumatoid arthritis;  mast cells;  autoimmune disease
分类号:
R 593.22
DOI:
10.3969/j.issn.2095-0411.2016.06.006
文献标志码:
A
摘要:
类风湿关节炎是一种自身免疫疾病,其主要特征是关节滑膜的慢性炎症,但是它的发病机制仍然不详。越来越多的证据表明肥大细胞在类风湿关节炎的发病中扮演者重要角色。肥大细胞通过多种途径参与类风湿关节炎的发病过程。肥大细胞激活释放出的大量炎性介质引起关节腔微环境的改变,诱导其他免疫细胞的募集并激活其他滑膜细胞和肥大细胞共同参与炎症和组织损伤过程。近年来,以肥大细胞作为类风湿治疗靶细胞已经成为药物开发的热点,深入研究和探讨肥大细胞的生物学特性及其与类风湿疾病发展的关系,将有助于进一步理解类风湿的病理机制,并为其靶向治疗开辟新途径。
Abstract:
Rheumatoid arthritis(RA)is an autoimmune disease characterized by chronic inflammation of the synovial lining of the joint, and its pathogenesis remains unknown. More and more evidences indicated that mast cells(MCs)play a critical role in the pathogenesis of RA and are participated through various pathways in the RA processing. Activated MCs release a large number of inflammatory mediators causing the changes of the microenvironment of the joint cavity, which induces the recruitment of other immune cells and the activation of other type of synovial cells, along with MCs together involved in the process of inflammation and tissue damage. Recently, mast cell as the therapeutic target for RA diseases is becoming a focus of new drug development, therefore, studying and discussing the biological characteristics and functions of mast cells and their relationships with RA progress in depth will help to understand the pathological mechanisms and to open a new avenue for the therapy of RA.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2016-05-28。基金项目:常州大学高层次人才引进启动基金(ZMF14020066); 常州科技局国际交流研究基金(KYJ1520305); 英国British Medical Research Council, UK(G0500729)。作者简介:周晓鹰(1957—),女,博士,常州大学外籍特聘教授,英国南安普顿大学客座教授。
更新日期/Last Update: 2016-11-20